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M7694

Sigma-Aldrich

Mupirocin

≥92% (HPLC), powder

Sinonimo/i:

5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester, BRL 4910A, Pseudomonic acid

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CHF 403.00
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CHF 725.00

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50 MG
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About This Item

Formula empirica (notazione di Hill):
C26H44O9
Numero CAS:
12650-69-0
Peso molecolare:
500.62
Numero MDL:
MFCD01711620
Codice UNSPSC:
12352200
ID PubChem:
24724542
NACRES:
NA.77

CHF 403.00

Spedizione prevista il17 maggio 2025

Richiedi un ordine bulk

Livello qualitativo

100

Saggio

≥92% (HPLC)

Stato

powder

Attività ottica

[α]/D -15.7 to -20°, c = 1 in methanol

Colore

white to tan

Solubilità

DMSO: ≥10 mg/mL

Spettro attività antibiotica

fungi

Modalità d’azione

enzyme | inhibits
protein synthesis | interferes

Ideatore

GlaxoSmithKline

Temperatura di conservazione

room temp

Stringa SMILE

[H][C@@]1(CO[C@@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)[C@H](O)[C@@H]1O)C[C@@H]2O[C@@]2([H])[C@@H](C)[C@H](C)O

InChI

1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1
MINDHVHHQZYEEK-HBBNESRFSA-N

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Descrizione generale

Mupirocin is produced by Pseudomonas fluorescens. Mupirocin is used to treat impetigo and skin infections.[1]

Applicazioni

Mupirocin has been used:
  • for kinetic assay[2]
  • to assess its resistance by performing turbidity assay[3][4]
  • to determine its antimicrobial susceptibility[5]

Azioni biochim/fisiol

Antibiotic; inhibits isoleucyl-tRNA synthetase (IRS).

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

Mupirocin is poorly soluble in water (26 mg/L), but highly soluble in DMSO (≥10 mg/mL). If sterilization is required, it is advisable to use filter sterilization with a 0.22 µm PTFE, Polypropylene, or Nylon filter membrane.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000126725
0000126724
101M4750V
0000167429
106M4733V

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Parenti MA, et al.
Clinical Pharmacy, 6(10), 761-770 (1987)
Eduardo Pérez-Roth et al.
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Questions

  1. Can this antibiotic be autoclaved?

    1 answer

    1. The heat stability of Mupirocin has not been tested. It is poorly soluble in water (26 mg/L), but highly soluble in DMSO (≥10 mg/mL). Should sterilization be necessary, filter sterilization using a 0.22 um PTFE, Polypropylene, or Nylon filter membrane is recommended. One publication does suggest that this compound may be autoclaved, however this has not been validated.

      See the link below for a publication that may be helpful:
      https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=04422266ee0024deeab81bd939305cbb1e2bc261

      Helpful?

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