M6635
N-(2-Mercaptopropionyl)glycine
Sinonimo/i:
Tiopronin
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About This Item
Formula condensata:
CH3CH(SH)CONHCH2COOH
Numero CAS:
Peso molecolare:
163.19
Beilstein:
1859822
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
NACRES:
NA.26
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Saggio
≥98% (TLC)
Stato
powder
Colore
white
Punto di fusione
98-100 °C
applicazioni
cell analysis
peptide synthesis
Stringa SMILE
CC(S)C(=O)NCC(O)=O
InChI
1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
YTGJWQPHMWSCST-UHFFFAOYSA-N
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Categorie correlate
Applicazioni
N-(2-Mercaptopropionyl)glycine or Tiopronin has been used:
- in the preparation of polyethylenimine (PEI)-coated gold microparticles (PEI-gold) for biolistic delivery of nucleic acids[1]
- to study the role of reactive oxygen species (ROS) at the reperfusion stage in in vivo isoflurane preconditioning-induced neuroprotection[2]
- as a ROS inhibitor to study its effect on lysophosphatidylcholine (LPC)-induced inflammasome activation[3]
Azioni biochim/fisiol
N-(2-Mercaptopropionyl)glycine (NMPG) is a thiol compound associated with autoimmune hypoglycemia.[4] It is a diffusible antioxidant and reduces the severity of colonic injury. NMPG also relieves myeloperoxidase activity and stimulates hypoxia-inducible factor-1 (HIF-1) - vascular endothelial growth factor (VEGF) pathway for ulcer healing.[5]
N-(2-Mercaptopropionyl)glycine is a free radical scavenger.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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I clienti hanno visto anche
Sang Hyun Lee et al.
Brain research, 1723, 146405-146405 (2019-08-28)
In this in vivo and in vitro study, we aimed to investigate whether isoflurane preconditioning-induced neuronal protection is mediated by reactive oxygen species (ROS) signaling at the reperfusion stage. In the in vivo study, Sprague-Dawley rats were subjected to middle
Wei Chen et al.
Journal of cardiovascular pharmacology, 73(5), 265-271 (2019-05-15)
Emulsified isoflurane (EI) has been shown to alleviate myocardial ischemia-reperfusion (IR) injury. However, previous reports have not been focused on the underlying mechanism. We used models of IR injury in Langendorff-isolated rat hearts to determine the relationship between the mechanism
Pyritinol
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 2988-2989 (2006)
Soohwan Yum et al.
Biochemical and biophysical research communications, 443(3), 1008-1013 (2013-12-24)
We investigated anti-colitic effects of N-(2-mercaptopropionyl)-glycine (NMPG), a diffusible antioxidant, in TNBS-induced rat colitis model and a potential molecular mechanism underlying the pharmacologic effect of the antioxidant. NMPG alleviated colonic injury and effectively lowered myeloperoxidase activity. Moreover, NMPG substantially attenuated
Mildred Quintana et al.
Chemical communications (Cambridge, England), 48(100), 12159-12161 (2012-10-24)
Under ultrasonication, the production of high quality graphene layers by exfoliation of graphite was achieved via addition of tiopronin as an antioxidant.
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