M5273

Monensin sodium salt

90-95% (TLC), Sodium ionophore

• Sinonimo/i: Monensin A sodium salt
• Formula empirica (notazione di Hill): C₃₆H₆₁NaO₁₁
• Numero CAS: 22373-78-0
• Peso molecolare: 692.85
• NACRES: NA.77
• PubChem Substance ID: 24896992
• UNSPSC Code: 12352200
• EC Number: 244-941-7
• MDL number: MFCD00077826
• Beilstein/REAXYS Number: 4122200
• Assay: 90-95% (TLC)

Proprietà

• Nome del prodotto: Monensin sodium salt, 90-95% (TLC)
• Quality Segment: 200
• assay: 90-95% (TLC)
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, viruses
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1
• InChI key: XOIQMTLWECTKJL-BEMBKCOJSA-M

Descrizione

General description

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:

• for the intracellular staining of cytokines
• to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
• as a positive control to study its effects on in vitro rumen fermentation

Biochem/physiol Actions

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Informazioni sulla sicurezza

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300,H319,H373,H411
• pcodes: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• target_organs: Heart,muscle
• Classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges