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M0317

Microsomes from Liver, Pooled

Name: Microsomes from Liver, Pooled
Brand: SIGMA

from human

Sinonimo/i:

Liver Microsomes

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

NACRES:

NA.47

UNSPSC Code:

12161501

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Proprietà

biological source

human

Quality Level

200

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

Descrizione

Application

Microsomes from liver have been used to study the in vitro effect of Clinacanthus nutans leaves on the activity of cytochrome P450 3A4 and 2E1.

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Source of drug metabolizing enzymes, including cytochrome P-450.

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Questo articolo	M9566	S2192	S2067
Sigma-Aldrich M0317 Microsomes from Liver, Pooled	Sigma-Aldrich M9566 Microsomes from Liver, Pooled	Sigma-Aldrich S2192 S9 from Liver, Pooled	Sigma-Aldrich S2067 S9 from Liver, Pooled
biological source human	biological source mouse (CD-1)	biological source mouse (CD-1)	biological source rat (Sprague-Dawley)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
packaging vial of ~10 mg	packaging vial of ~10 mg	packaging vial of 1.0 mL	packaging vial of ~20 mg
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in dry ice
storage temp. −70°C	storage temp. −70°C	storage temp. −70°C	storage temp. −70°C

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Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Contenuto correlato

Data Sheet - M0317

Datasheet

Novel CYP11B-ligand [123/131I]IMAZA as promising theranostic tool for adrenocortical tumors: comprehensive preclinical characterization and first clinical experience.

Britta Heinze et al.

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Adrenal tumors represent a diagnostic and therapeutic challenge. Promising results have been obtained through targeting the cytochrome P450 enzymes CYP11B1 and CYP11B2 for molecular imaging, and [123/131I]iodometomidate ([123/131I]IMTO) has even been successfully introduced as a theranostic agent. As this radiopharmaceutical

In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans.

Verawan Uchaipichat

Drug metabolism and pharmacokinetics, 33(1), 67-76 (2017-12-16)

This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo.

Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans

Sukh Yen Khua

Drug metabolism and personalized therapy (2017)

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Numero articolo commerciale globale

SKU	GTIN
M0317-1VL	04061833992999