J4144
Jo-1 human
recombinant, expressed in E. coli, solution
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 100 μg | Per conoscere la disponibilità, visualizza il carrello | CHF 413.00 |
Informazioni su questo articolo
Form:
solution
Recombinant:
expressed in E. coli
Mol wt:
55 kDa by SDS-PAGE
Servizio Tecnico
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Permettici di aiutartirecombinant
expressed in E. coli
Quality Level
form
solution
mol wt
55 kDa by SDS-PAGE
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HARS(3035)
General description
Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.
Biochem/physiol Actions
The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.
Used in the immunoassay for antibodies to Jo-1.
Physical form
Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.
1 of 1
Questo articolo | |||
|---|---|---|---|
| recombinant expressed in E. coli | recombinant expressed in CHO cells | recombinant expressed in CHO cells | recombinant expressed in HEK 293 cells |
| mol wt 55 kDa by SDS-PAGE | mol wt monomer 57 kDa by calculation | mol wt monomer 46 kDa by calculation | mol wt ~150 kDa by SDS-PAGE |
| form solution | form lyophilized | form lyophilized | form lyophilized |
| Gene Information human ... HARS(3035) | Gene Information human ... HAVCR1(26762) | Gene Information human ... PDCD1(5133) | Gene Information human ... JAG2(3714) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| shipped in dry ice | shipped in wet ice | shipped in wet ice | shipped in wet ice |
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenuto correlato
Instructions
M Nishikai et al.
British journal of rheumatology, 37(4), 357-361 (1998-06-10)
We evaluated an enzyme-linked immunosorbent assay (ELISA) for detecting anti-Jo-1 antibodies in patients with polymyositis (PM) or dermatomyositis (DM) by use of the recombinant fusion protein Jo-1. Sera from 64 patients with PM or DM, from 80 patients with other
Luis M Molinos-Albert et al.
Nature communications, 13(1), 1944-1944 (2022-04-13)
HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| J4144-100UG | 04061838071422 |