I2002
Isocitric Dehydrogenase (NADP) from porcine heart
Type IV, buffered aqueous glycerol solution, 3-20 units/mg protein
Sinonimo/i:
threo-Ds-Isocitrate: NADP+ oxidoreductase, ICDH, IDH
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Scegli un formato
Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 102.00 | |
| 100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 486.00 | |
| 250 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 724.00 | |
| 500 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 1’210.00 |
Informazioni su questo articolo
Numero CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
200-289-5
MDL number:
Specific activity:
3-20 units/mg protein
CHF 102.00
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartitype
Type IV
Quality Level
form
buffered aqueous glycerol solution
quality
≤ 0.2% of main activity is obtained with NAD as cofactor.
specific activity
3-20 units/mg protein
composition
Protein biuret
shipped in
wet ice
storage temp.
2-8°C
Application
Biochem/physiol Actions
Isocitrate dehydrogenase (IDH) is a homodimeric enzyme and participates in several processes such as adapting to hypoxia, histone demethylation, and DNA modification. This enzyme has three isoforms like IDH1, IDH2, and IDH3.[3]
Physical form
Solution in 50% glycerol in EDTA buffer salts, pH 6.0
Other Notes
One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37 °C.
1 of 1
Questo articolo | |||
|---|---|---|---|
| specific activity 3-20 units/mg protein | specific activity 600-1000 units/mg protein (biuret) | specific activity - | specific activity - |
| form buffered aqueous glycerol solution | form buffered aqueous glycerol solution | form buffered aqueous solution | form buffered aqueous solution |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| shipped in wet ice | shipped in wet ice | shipped in dry ice | shipped in dry ice |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level - |
| type Type IV | type - | type - | type - |
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 2
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Avtar Singh et al.
The Journal of biological chemistry, 278(35), 33208-33216 (2003-06-07)
Transhydrogenase couples the reduction of NADP+ by NADH to inward proton translocation across mitochondrial and bacterial membranes. The coupling reactions occur within the protein by long distance conformational changes. In intact transhydrogenase and in complexes formed from the isolated, nucleotide-binding
Icksoo Lee et al.
Biochimica et biophysica acta, 1802(2), 275-283 (2009-10-20)
Noonan syndrome (NS) is an autosomal dominant disorder, and a main feature is congenital heart malformation. About 50% of cases are caused by gain-of-function mutations in the tyrosine phosphatase SHP2/PTPN11, a downstream regulator of ERK/MAPK. Recently it was reported that
Sergiy M Nadtochiy et al.
The Journal of biological chemistry, 291(38), 20188-20197 (2016-08-12)
2-Hydroxyglutarate (2-HG) is an important epigenetic regulator, with potential roles in cancer and stem cell biology. The d-(R)-enantiomer (d-2-HG) is an oncometabolite generated from α-ketoglutarate (α-KG) by mutant isocitrate dehydrogenase, whereas l-(S)-2-HG is generated by lactate dehydrogenase and malate dehydrogenase
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| I2002-250MG | 04061832730431 |
| I2002-25MG | 04061832730448 |
| I2002-25G-A | 04061833848241 |
| I2002-5G-A | 04061832490205 |
| I2002-100MG | 04061833848234 |
| I2002-500MG | 04061832730455 |