H0652
Anti-Hepatocyte Growth Factor antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Sinonimo/i:
Anti-HGF
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About This Item
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
IgG fraction of antiserum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
lyophilized powder
Reattività contro le specie
human
tecniche
neutralization: suitable
western blot: suitable
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... HGF(3082)
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Descrizione generale
Hepatocyte Growth Factor (HGF) is a multifunctional, heparin-binding factor that stimulates the proliferation of liver cells. The cellular effects of HGF are mediated by its receptor, c-Met, that leads to significant activation of ERK, Src/FAK, STAT3 and PI3K signaling. Cells of mesenchymal origin express HGF that stimulates the c-Met expression via an autocrine loop. Various functions of the HGF/c-Met signaling include proliferation, cell survival, motility and adhesion and tissue regeneration. Apart from liver, HGF also mediates regeneration of kidney, lung and gastro-intestines. It is also important for maintaining the insulin production and prevents hypoglycemia, self-repair of cartilage, muscle and skin and hematopoiesis. The HGF/c-Met signaling is reported as a promising therapeutic target in prevention of angiogenesis in cancer and maintaining synaptic plasticity in Alzheimer′s disease
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF.
Monoclonal Anti-Hepatocyte Growth Factor recognizes human HGF.
Immunogeno
recombinant human hepatocyte growth factor.
Applicazioni
Anti-Hepatocyte Growth Factor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml is recommended. The antibody is suitable for neutralization reactions. A concentration of 500ng/ml of anti-HGF has been used to neutralize HGF in the conditioned medium of NIH3TS cells. Anti-HGF has been used at a working concentration of 20μg/ml for immunohistochemistry of section of cervical lesions.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Nota sulla preparazione
Purified by Protein G.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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Francine Walker et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(1), 273-284 (2003-01-23)
High prevalence of squamous cervical intraepithelial neoplasia (CIN) linked to oncogenic human papillomavirus (HPV) exits in HIV-infected women. Hepatocyte growth factor (HGF) and its receptor, c-Met, promote cell proliferation and are involved in tumor progression. Nothing is yet known about
Lei Zhuang et al.
Oncology reports, 42(5), 1781-1792 (2019-09-06)
Cardiac fibrosis is a pathological consequence of radiation‑induced fibroblast proliferation and fibroblast‑to‑myofibroblast transition (FMT). Mesenchymal stem cell (MSC) transplantation has been revealed to be an effective treatment strategy to inhibit cardiac fibrosis. We identified a novel MSC‑driven mechanism that inhibited
Nai-Chen Cheng et al.
Frontiers in cell and developmental biology, 8, 558354-558354 (2020-11-17)
Adipose-derived stem cell (ASC) is a valuable source of cell therapy. By stimulating extracellular matrix (ECM) secretion, ASC sheets can be fabricated with enhanced regenerative capabilities. In recent years, human platelet lysate (HPL) provides an attractive alternative to fetal bovine
Y Ueoka et al.
British journal of cancer, 82(4), 891-899 (2000-03-25)
Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic biological effects on epithelial cells such as proliferation, motogenesis, invasiveness and morphogenesis. Peritoneal dissemination is critical for the progression of ovarian cancer, and our study revealed that HGF
Chunsun Dai et al.
The Journal of biological chemistry, 278(29), 27080-27087 (2003-05-15)
Type I diabetes is an autoimmune disease that results in destructive depletion of the insulin-producing beta cells in the islets of Langerhans in pancreas. With the knowledge that hepatocyte growth factor (HGF) is a potent survival factor for a wide
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