F7807
Prostaglandin F Synthase human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Sinonimo/i:
17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 50 μg | Per conoscere la disponibilità, visualizza il carrello | CHF 435.00 |
Informazioni su questo articolo
Numero CAS:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Specific activity:
≥0.4 μmol/mg protein
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in E. coli
CHF 435.00
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
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Permettici di aiutartirecombinant
expressed in E. coli
Quality Level
description
contains a C-terminal hexahistidine tag
assay
≥90% (SDS-PAGE)
form
liquid
specific activity
≥0.4 μmol/mg protein
mol wt
~37 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AKR1C3(8644)
Application
Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma [1].
Biochem/physiol Actions
PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways [2].
Other Notes
One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone
1 of 1
Questo articolo | |||
|---|---|---|---|
| Gene Information human ... AKR1C3(8644) | Gene Information human ... ALDH2(217) | Gene Information human ... AKR1D1(6718) | Gene Information - |
| assay ≥90% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay - | assay ≥94% (HPLC) |
| specific activity ≥0.4 μmol/mg protein | specific activity - | specific activity - | specific activity - |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant - | recombinant - |
| form liquid | form liquid | form buffered aqueous solution | form solid |
| storage temp. −70°C | storage temp. −70°C | storage temp. −20°C | storage temp. 2-8°C |
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Marta Wasielak et al.
Reproduction, fertility, and development, 21(5), 709-717 (2009-06-03)
The present study was conducted to evaluate the effect of the conceptus on uterine prostaglandin-F2alpha (PGF2alpha) and prostaglandin-E2 (PGE2) release and the expression of prostaglandin synthase enzymes during the periimplantation period in the pig. A surgically generated model with conceptuses
Dominika Slonina et al.
Prostaglandins & other lipid mediators, 90(3-4), 69-75 (2009-09-15)
The aim was to study whether bovine myometrial cells have an enzymatic system able to produce prostaglandins (PGs) and whether PGs synthesis is regulated by steroids in a similar manner as endometrial cells. In Experiment 1, immunohistochemical studies localized proteins
Mariusz Pawel Kowalewski et al.
Animal reproduction science, 116(1-2), 129-138 (2009-01-24)
In nonpregnant and pregnant dogs the corpora lutea (CL) are the only source of progesterone (P4) which shows an almost identical secretion pattern until the rapid decrease of P4 prior to parturition. For the nonpregnant dog clear evidence has been
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| F7807-50UG | 04061832729527 |