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F4765

Fluphenazine dihydrochloride

Sinonimo/i:

4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C22H26F3N3OS · 2HCl
Numero CAS:
Peso molecolare:
510.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-674-1
MDL number:

SMILES string

Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H

InChI key

MBHNWCYEGXQEIT-UHFFFAOYSA-N

Gene Information

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General description

Fluphenazine may be useful for the treatment of schizophrenia.

Application

Fluphenazine dihydrochloride has been used:
  • to study its effects as a drug on glioblastoma (GBM) cells
  • in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
  • to study its exposure effects on learning and memory in adult rats

Biochem/physiol Actions

D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1A

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Principles of Psychopharmacology for Mental Health Professionals (2006)
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Yaakov G, et al.
Nature ecology & evolution, 1(1), 0016-0016 (2017)
G Cai et al.
Molecular pharmacology, 56(5), 989-996 (1999-10-26)
The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(1A) dopamine receptor, using the ligand [(125)I]SCH23982 were 0.38 +/- 0.09 nM
The Effect of Intrauterine Antipsychotic Drug Exposure on Learning and Memory in Adult Rats
Oltulu C and Karadag CH
Klinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology, 26(4), 364-373 (2016)
Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data
Cheng HW, et al.
Cell Death & Disease, 6(5), e1753-e1753 (2015)

Numero articolo commerciale globale

SKUGTIN
F4765-1G04061825982250
F4765-5G04061832090832

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