E3148

Endomorphin 2

• Formula empirica (notazione di Hill): C₃₂H₃₇N₅O₅
• Numero CAS: 141801-26-5
• Peso molecolare: 571.67
• Numero MDL: MFCD01321064
• Codice UNSPSC: 12352200
• ID PubChem: 329799042

Proprietà

• Temperatura di conservazione: −20°C
• Stringa SMILE: N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4ccccc4)C(N)=O
• InChI: 1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1; XIJHWXXXIMEHKW-LJWNLINESA-N
• Informazioni sul gene: human ... OPRM1(4988) ; mouse ... OPRM1(18390) ; rat ... OPRM1(25601)

Descrizione

Amino Acid Sequence

Tyr-Pro-Phe-Phe-NH2

Descrizione generale

Endomorphin 2 is an endogenous ligand for μ-opioid receptor (MOR). It is a neuropeptide and has the sequence Tyr-Pro-Phe-Phe-NH2. It has a greater affinity for MOR1 receptor than MOR2. It resides in primary sensory afferent fibers, and might be the predominant ligand to regulate pain perception. In dynorphin-induced allodynia mice models, endomorphin has anti-allodynic effects. In tail flick test, it produces short-lived antinociception, which is naloxone-sensitive.

Azioni biochim/fisiol

Potent, selective endogenous μ opioid receptor agonist.

Note legali

Sold under license to US patent number 6,303,578

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)