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E1406

Sigma-Aldrich

Embelin

≥98% (HPLC), powder

Sinonimo/i:

2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione, Embelic acid, Emberine

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10 MG
CHF 125.00
50 MG
CHF 413.00

CHF 125.00

Spedizione prevista il17 aprile 2025

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10 MG
CHF 125.00
50 MG
CHF 413.00

About This Item

Formula empirica (notazione di Hill):
C17H26O4
Numero CAS:
550-24-3
Peso molecolare:
294.39
Numero CE:
208-979-8
Numero MDL:
MFCD00016369
Codice UNSPSC:
12352200
ID PubChem:
24724473
NACRES:
NA.77

CHF 125.00

Spedizione prevista il17 aprile 2025

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Livello qualitativo

200

Saggio

≥98% (HPLC)

Stato

powder

Solubilità

DMSO: >10 mg/mL
H2O: insoluble

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
parasites

Modalità d’azione

DNA synthesis | interferes

Stringa SMILE

CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O

InChI

1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
IRSFLDGTOHBADP-UHFFFAOYSA-N

Informazioni sul gene

human ... XIAP(331)

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Categorie correlate

Descrizione generale

Embelin, a natural benzoquinone-derivative, was initially extracted from Embelia ribes plant.[1] It is structurally similar to ubiquinone.[2]

Applicazioni

Embelin has been used:
  • to study its effects on the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced nuclear factor of activated T cells (NFATc1) luciferase activity[3]
  • to study its role in the mechanisms mediating Parkinson′s disease (PD)[2]
  • in treating whole mouse embryos to determine its effects on the X-linked inhibitory apoptosis protein (XIAP) activity[1]

Azioni biochim/fisiol

Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity.
Embelin elicits anti-oxidant, mitochondrial uncoupling, and anti-fertility properties.[2][4] It also has anti-diabetic, anti-convulsant, anxiolytic, and anti-microbial activities.[4] Embelin acts as a potent neuroprotective agent and is also beneficial as an adjunct therapy for cerebral stroke.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361f

Consigli di prudenza

P201 - P308 + P313

Classi di pericolo

Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000273474
0000273474
0000267261
016M4740V

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Reagente di Schiff

Feng Li et al.
Biomacromolecules, 11(10), 2610-2620 (2010-09-02)
The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8)
Uday P Kundap et al.
Frontiers in pharmacology, 8, 76-76 (2017-03-16)
A Central nervous system (CNS) disease is the one which affects either the spinal cord or brain and causing neurological or psychiatric complications. During the nineteenth century, modern medicines have occupied the therapy for many ailments and are widely used
Boreddy Shivanandappa Thippeswamy et al.
European journal of pharmacology, 654(1), 100-105 (2010-12-28)
The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100mg/kg, p.o.) for five consecutive
Yixian Huang et al.
Bioconjugate chemistry, 23(7), 1443-1451 (2012-06-12)
Embelin, identified primarily from the Embelia ribes plant, has been shown to be a natural small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It is also a potent inhibitor of NF-κB activation, which makes it a potentially effective
G Kalyan Kumar et al.
European journal of pharmacology, 662(1-3), 63-69 (2011-05-10)
Tumor necrosis factor-α (TNF-α) is known to play a crucial role in the pathogenesis of psoriasis. The present study was designed to investigate the effects of embelin on lipopolysachharide induced TNF-α production in mice and in human keratinocytes in vitro
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NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

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