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E1406

Embelin

≥98% (HPLC), powder

Sinonimo/i:

2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione, Embelic acid, Emberine

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
10 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 131.00
50 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 430.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C17H26O4
Numero CAS:
550-24-3
Peso molecolare:
294.39
NACRES:
NA.77
PubChem Substance ID:
24724473
UNSPSC Code:
12352200
EC Number:
208-979-8
MDL number:
MFCD00016369
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200

CHF 131.00

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Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMSO: >10 mg/mL, H2O: insoluble

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, parasites

mode of action

DNA synthesis | interferes

SMILES string

CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O

InChI

1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3

InChI key

IRSFLDGTOHBADP-UHFFFAOYSA-N

Gene Information

human ... XIAP(331)

General description

Embelin, a natural benzoquinone-derivative, was initially extracted from Embelia ribes plant.[1] It is structurally similar to ubiquinone.[2]

Application

Embelin has been used:
  • to study its effects on the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced nuclear factor of activated T cells (NFATc1) luciferase activity[3]
  • to study its role in the mechanisms mediating Parkinson′s disease (PD)[2]
  • in treating whole mouse embryos to determine its effects on the X-linked inhibitory apoptosis protein (XIAP) activity[1]

Biochem/physiol Actions

Embelin is an inhibitor of XIAP (X-linked inhibitor-of-apoptosis protein); in vivo antitumor and anti-inflammatory activity.
Embelin elicits anti-oxidant, mitochondrial uncoupling, and anti-fertility properties.[2][4] It also has anti-diabetic, anti-convulsant, anxiolytic, and anti-microbial activities.[4] Embelin acts as a potent neuroprotective agent and is also beneficial as an adjunct therapy for cerebral stroke.

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Questo articolo
178493PHL89654I5659
Embelin ≥98% (HPLC), powder

Sigma-Aldrich

E1406

Embelin

Apoptosis Activator III, Embelin The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

178493

Apoptosis Activator III, Embelin

Embelin phyproof® Reference Substance

PHL89654

Embelin

Idebenone ≥98% (HPLC)

Sigma-Aldrich

I5659

Idebenone

form

powder

form

solid

form

-

form

powder

assay

≥98% (HPLC)

assay

-

assay

≥90.0% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

200

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, methanol: 5 mg/mL

solubility

-

solubility

methanol: 50 mg/mL, clear to slightly hazy

mode of action

DNA synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, parasites, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361f

Hazard Classifications

Repr. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000273474
0000273474
0000267261
0000267261
0000150865

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Articoli

NF-κB and Inflammation

Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

Simone Reuter et al.
Molecular cancer research : MCR, 8(10), 1425-1436 (2010-09-10)
Most patients with cancer die not because of the tumor in the primary site, but because it has spread to other sites. Common tumors, such as breast, multiple myeloma, and prostate tumors, frequently metastasize to the bone. It is now
Rajnish Gupta et al.
Journal of diabetes, 4(3), 248-256 (2012-01-19)
The aim of the present study was to evaluate the antioxidant potential of embelin in streptozotocin-induced diabetes. Diabetes was induced in rats fasted overnight by the administration of a single dose of streptozotocin, and analyzed for blood, serum, and biological
Swetha Pavani Rao et al.
Biochimica et biophysica acta. Bioenergetics, 1861(3), 148157-148157 (2020-01-29)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor deficits. Amongst the mechanisms proposed, mitochondrial dysfunction, reduced complex-I and PGC1α levels were found to correlate
Visualizza tutti i documenti correlati

Numero articolo commerciale globale

SKUGTIN
E1406-50MG04061833601808
E1406-10MG04061833601792

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