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E114

Sigma-Aldrich

EHNA hydrochloride

≥98% (HPLC), powder, adenosine deaminase inhibitor

Sinonimo/i:

erythro-9-(2-Hydroxy-3-nonyl)­adenine hydrochloride, erythro-9-Amino-β-hexyl-­α-methyl-9H-purine-9-ethanol hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C14H23N5O · HCl
Numero CAS:
58337-38-5
Peso molecolare:
313.83
Numero MDL:
MFCD00151066
Codice UNSPSC:
12352200
ID PubChem:
24277713
NACRES:
NA.77

product name

EHNA hydrochloride, ≥98% (HPLC)

Livello qualitativo

100

Saggio

≥98% (HPLC)

Condizioni di stoccaggio

desiccated

Solubilità

DMSO: >10 mg/mL
H2O: >10 mg/mL

Stringa SMILE

Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12

InChI

1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
VVDXNJRUNJMYOZ-VZXYPILPSA-N

Informazioni sul gene

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

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Descrizione generale

EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.

Applicazioni

EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.

Azioni biochim/fisiol

Adenosine deaminase inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines.
H J Schaeffer et al.
Journal of medicinal chemistry, 17(1), 6-8 (1974-01-01)
Sarah M Bowers et al.
Pediatric rheumatology online journal, 18(1), 54-54 (2020-07-12)
Human adenosine deaminase 2 (ADA2) is an extracellular enzyme that negatively regulates adenosine-mediated cell signaling by converting adenosine to inosine. Altered ADA2 enzyme activity has been associated with some viral infections and rheumatic diseases. The potential utility of ADA2 as
Dynein-and activity-dependent retrograde transport of autophagosomes in neuronal axons
Katsumata K, et al.
Autophagy, 6(3), 378-385 (2010)
Heidi M B Lesscher et al.
Alcoholism, clinical and experimental research, 41(7), 1271-1279 (2017-04-28)
A substantial part of the risk for alcohol use disorder is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a quantitative trait loci (QTL) for alcohol preference on mouse chromosome 2. The aim of this
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma
Nakajima Y, et al.
Cellular Physiology and Biochemistry, 35(1), 51-60 (2015)
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