D8446
P7C3
≥98% (HPLC)
Sinonimo/i:
3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 129.00 CHF 109.65 | |
| 25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 475.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C21H18Br2N2O
Numero CAS:
Peso molecolare:
474.19
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
CHF 109.65
Prezzo di listinoCHF 129.00Risparmia il 15%Promozione valida solo online
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
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Permettici di aiutartiQuality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: 34 mg/mL
storage temp.
2-8°C
SMILES string
OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
InChI
1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
InChI key
FZHHRERIIVOATI-UHFFFAOYSA-N
Application
P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus.[1] P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.[2]
Biochem/physiol Actions
P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.
P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.
Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.
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Questo articolo | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp |
| solubility DMSO: 34 mg/mL | solubility DMSO: ≥30 mg/mL | solubility DMSO: >10 mg/mL | solubility DMSO: 5 mg/mL, clear (warmed) |
| color white to off-white | color yellow | color yellow to orange | color white to beige |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1
Classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A K Walker et al.
Molecular psychiatry, 20(4), 500-508 (2014-04-23)
Augmenting hippocampal neurogenesis represents a potential new strategy for treating depression. Here we test this possibility by comparing hippocampal neurogenesis in depression-prone ghrelin receptor (Ghsr)-null mice to that in wild-type littermates and by determining the antidepressant efficacy of the P7C3
Hidehiro Oku et al.
Japanese journal of ophthalmology, 61(2), 195-203 (2016-12-30)
To determine whether P7C3-A20, a proneurogenic neuroprotective agent, can protect the retinal ganglion cells (RGCs) of rats from optic nerve crushing. The left optic nerve of 67 rats was crushed, and 5.0 mg/kg/day of P7C3-A20 (crush-P7C3) or its vehicle (crush-placebo) was
Rachel Tesla et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(42), 17016-17021 (2012-10-03)
We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in newborn neural precursor cells of the hippocampal dentate gyrus. We have further found that chemicals having efficacy in this in vivo screening assay also
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| D8446-5MG | 04061833234303 |
| D8446-25MG | 04061833234297 |