D6539
2-Deoxy-α-D-ribose 1-phosphate bis(cyclohexylammonium) salt
≥97% (TLC)
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C5H11O7P · 2C6H13N
Numero CAS:
Peso molecolare:
412.46
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
Beilstein/REAXYS Number:
3785872
biological source
synthetic (organic)
Quality Level
assay
≥97% (TLC)
form
powder
color
white
solubility
water: 50 g/L at 20 °C
storage temp.
−20°C
SMILES string
NC1CCCCC1.NC2CCCCC2.OC[C@H]3O[C@@H](C[C@@H]3O)OP(O)(O)=O
InChI
1S/2C6H13N.C5H11O7P/c2*7-6-4-2-1-3-5-6;6-2-4-3(7)1-5(11-4)12-13(8,9)10/h2*6H,1-5,7H2;3-7H,1-2H2,(H2,8,9,10)/t;;3-,4+,5+/m..0/s1
InChI key
GVYUZZDUVZHJAM-CGKAESPRSA-N
Application
2-Deoxyribose 1-phosphate (2dR1P) may be used in pyrimidine metabolism research to identify and characterize thymidine phosphorylase(s)/platelet-derived endothelial cell growth factor(s)(PD-ECGF)/gliostatin(s).[1] 2-Deoxyribose 1-phosphate may be used to study processes such as angiogenesis in tumor cells at the level of thymidine phosphorylase activity.[2] 2-Deoxy-a-D-ribose 1-phosphate (dR-1-P) is used in the organic synthesis of 2′-deoxynucleosides such as cladribine.[3]
Preparation Note
Enzymatically prepared
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hironori Komatsu et al.
Nucleosides, nucleotides & nucleic acids, 24(5-7), 1127-1130 (2005-10-27)
Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
Candida Deves et al.
Molecular bioSystems, 10(3), 592-604 (2014-01-11)
Human Thymidine Phosphorylase (HTP), also known as the platelet-derived endothelial cell growth factor (PD-ECGF) or gliostatin, catalyzes the reversible phosphorolysis of thymidine (dThd) to thymine and 2-deoxy-α-d-ribose-1-phosphate (2dR1P). HTP is a key enzyme in the pyrimidine salvage pathway involved in
Dina S Vara et al.
Thrombosis and haemostasis, 109(6), 1108-1119 (2013-03-16)
Using direct injection mass spectrometry (DIMS) we discovered that deoxyribose-1-phosphate (dRP) is released by platelets upon activation. Interestingly, the addition of exogenous dRP to human platelets significantly increased platelet aggregation and integrin αIIbβ3 activation in response to thrombin. In parallel
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| D6539-250MG | 04061832389127 |
| D6539-100MG | 04061832389110 |
| D6539-5MG | 04061832389134 |