C1623

Anti-CLIC2 (233-247) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinonimo/i: Anti-CLIC2b, Anti-Chloride intracellular channel protein 2, Anti-XAP121
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 4

Proprietà

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~28 kDa
• species reactivity: human
• technique(s): western blot: 1:500-1:2,000
• UniProt accession no.: O15247
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CLIC2(1193)

Descrizione

General description

Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene in humans and belongs to chloride intracellular channel (CLIC) family. It is also referred as CLIC2b, MRXS32 and XAP121. CLIC2 protein is a member of the glutathione transferase class of proteins and they can exist as integral membrane-channel form or a soluble form. The gene is possibly associated with one of the many diseases linked to Xq28.

Immunogen

synthetic peptide corresponding to amino acids 233-247 of human CLIC2

Application

Anti-CLIC2 (233-247) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Chloride intracellular channel 2 (CLIC2) functions by regulating ryanodine receptor (RyR) intracellular Ca(2+) release channels. RyR proteins play a major role in the regulation of Ca(2+) signaling in many cells. CLIC2 protein also helps in maintaining normal cognitive function by interacting with RyRs in the brain. In healthy individuals it is studied that the CLIC2 protein can tolerate amino acid substitutions and can be fully functional.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.