C1618

Cibenzoline

≥98% (HPLC), solid

• Sinonimo/i: 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor
• Formula empirica (notazione di Hill): C₁₈H₁₈N₂ ·C₄H₆O₄
• Numero CAS: 100678-32-8
• Peso molecolare: 380.44
• NACRES: NA.77
• PubChem Substance ID: 24892426
• UNSPSC Code: 12352200
• MDL number: MFCD00941423
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: desiccated

Proprietà

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to brown
• solubility: H₂O: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4
• InChI: 1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)
• InChI key: XFUIOIWYMHEPIE-UHFFFAOYSA-N

Descrizione

General description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(−) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

Cibenzoline succinate inhibits ATP-sensitive K⁺ channels; class IA antiarrhythmic.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves