C1353
Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 0.05 mL | Per conoscere la disponibilità, visualizza il carrello | CHF 280.00 | |
| 0.2 mL | Per conoscere la disponibilità, visualizza il carrello | CHF 893.00 CHF 759.05 |
Informazioni su questo articolo
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
9
CHF 280.00
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
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Permettici di aiutartibiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen (major) 190 kDa, antigen (minor) 210 kDa
species reactivity
rat, mouse
technique(s)
immunohistochemistry: 1:100, western blot: 1:200
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Cacna1a(12286)
rat ... Cacna1a(25398)
Immunogen
synthetic peptide corresponding to amino acids 865-881 of the α1A subunit of rat brain voltage-gated calcium channel (VGCC, CNA1) (with additional N-terminal lysine and tyrosine) conjugated to KLH.
Application
Anti-Calcium Channel (α1A Subunit) (P/Q-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit is suitable for immunohistochemistry at a dilution of 1:100 and western blotting at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunoprecipitation (1 paper)
Immunoprecipitation (1 paper)
Biochem/physiol Actions
The Cav2.1 P/Q voltage-dependent calcium channel is encoded by the CACNA1A gene in humans. It is a pore-forming essential subunit embedded in the plasma membrane. Mutation in this gene causes a number of human neurologic diseases including familial hemiplegic migraine. CACNA1A is associated with both hemiplegic migraine and migraine with aura in patients. Mutation in this gene is the cause of Type 2 episodic ataxia (EA2) the most common subtype among a group of rare hereditary syndromes characterized by recurrent attacks of ataxia.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Questo articolo | |||
|---|---|---|---|
| antibody form affinity isolated antibody | antibody form ascites fluid | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| biological source rabbit | biological source mouse | biological source rabbit | biological source rabbit |
| mol wt antigen (major) 190 kDa, antigen (minor) 210 kDa | mol wt antigen 143 kDa (reduced), antigen 220 kDa (non-reduced) | mol wt - | mol wt - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
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Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Steven B Condliffe et al.
The Journal of biological chemistry, 288(47), 33873-33883 (2013-10-11)
Mutations in the CACNA1A gene, which encodes the pore-forming α1A subunit of the CaV2.1 voltage-gated calcium channel, cause a number of human neurologic diseases including familial hemiplegic migraine. We have analyzed the functional impact of the E1015K amino acid substitution
Xue Liu et al.
The Journal of physiology, 591(13), 3309-3324 (2013-04-25)
Horizontal cells send inhibitory feedback to photoreceptors, helping form antagonistic receptive fields in the retina, but the neurotransmitter and the mechanisms underlying this signalling are not known. Since the proteins responsible for conventional Ca(2+)-dependent release of GABAergic synaptic vesicles are
Wei Chun Chen et al.
Hearing research, 278(1-2), 52-68 (2011-02-02)
As with other elements of the peripheral auditory system, spiral ganglion neurons display specializations that vary as a function of location along the tonotopic axis. Previous work has shown that voltage-gated K(+) channels and synaptic proteins show graded changes in
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| C1353-.05ML | 04061838172020 |
| C1353-.2ML | 04061838172037 |