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A4937

Anti-Mouse IgA (α-chain specific)−Alkaline Phosphatase antibody produced in goat

Name: Anti-Mouse IgA (α-chain specific)−Alkaline Phosphatase antibody produced in goat
Brand: SIGMA
Price: 193 CHF

affinity isolated antibody, buffered aqueous glycerol solution

Sinonimo/i:

Goat Anti-Mouse IgA (α-chain specific)−AP

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Cambia visualizzazione

Taglio della confezione	SKU	Disponibilità	Prezzo
0.5 mL		Per conoscere la disponibilità, visualizza il carrello	CHF 193.00
0.25 mL		Per conoscere la disponibilità, visualizza il carrello	CHF 239.00

Informazioni su questo articolo

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00162615

Conjugate:

alkaline phosphatase conjugate

Clone:

polyclonal

Application:

ELISA (d), WB

Citations:

CHF 193.00

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Proprietà

biological source

goat

Quality Level

200

conjugate

alkaline phosphatase conjugate

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

technique(s)

direct ELISA: 1:30,000, western blot: 1:30,000

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Descrizione

General description

Immunoglobulin A (IgA) is the major mammalian antibody isotype that is synthesized in the gut associated lymphoid tissues. This immunoglobulin isotype modulates intestinal microorganisms and has been implicated in the pathogenesis of IgA nephropathy. Anti-Mouse IgA (α-chain specific)-Alkaline Phosphatase antibody is specific for mouse IgA when tested against purified mouse IgA, IgG, and IgM myeloma proteins.

Immunogen

Purified mouse IgA

Application

E. coli lysates and purified pili were analyzed by western blot using alkaline phosphatase conjugated goat anti-mouse IgA antibody as a secondary.[1]

Anti-Mouse IgA (α-chain specific)-Alkaline Phosphatase antibody is suitable for use in ELISA. The product can also be used for western blot (1:30,000).

Physical form

Solution in 0.05 M Tris, pH 8.0, containing 1 mM MgCl₂, 10 mM glycine, 1% bovine serum albumin, 50% glycerol and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	A3438	A9316	A2429
Sigma-Aldrich A4937 Anti-Mouse IgA (α-chain specific)−Alkaline Phosphatase antibody produced in goat	Sigma-Aldrich A3438 Anti-Mouse IgG (γ-chain specific)−Alkaline Phosphatase antibody produced in goat	Sigma-Aldrich A9316 Anti-Mouse IgG (whole molecule)−Alkaline Phosphatase antibody produced in goat	Sigma-Aldrich A2429 Anti-Mouse IgG (Fc specific)–Alkaline Phosphatase antibody produced in goat
conjugate alkaline phosphatase conjugate	conjugate alkaline phosphatase conjugate	conjugate alkaline phosphatase conjugate	conjugate alkaline phosphatase conjugate
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
technique(s) direct ELISA: 1:30,000, western blot: 1:30,000	technique(s) direct ELISA: 1:30,000, dot blot: 1:30,000, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50, western blot: 1:30,000	technique(s) direct ELISA: 1:30,000, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50, western blot: 1:30,000	technique(s) direct ELISA: 1:30,000, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40, western blot (chemiluminescent): 1:160,000-1:320,000
biological source goat	biological source goat	biological source goat	biological source goat
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

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Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Contenuto correlato

Data Sheet - A4937

Instructions

IgA synthesis: a form of functional immune adaptation extending beyond gut.

Duncan B Sutherland et al.

Current opinion in immunology, 24(3), 261-268 (2012-04-17)

Immunoglobulin A (IgA) is the most abundantly produced antibody isotype in mammals. The primary function of IgA is to maintain homeostasis at mucosal surfaces. IgA is generated in specialized gut associated lymphoid tissues (GALT) by T cell-dependent and T cell-independent

Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili.

Finn Terje Hegge et al.

Proceedings of the National Academy of Sciences of the United States of America, 101(29), 10798-10803 (2004-07-14)

Several major bacterial pathogens and related commensal species colonizing the human mucosa express phosphocholine (PC) at their cell surfaces. PC appears to impact host-microbe biology by serving as a ligand for both C-reactive protein and the receptor for platelet-activating factor.

Adipose-derived stem cells improve renal function in a mouse model of IgA nephropathy.

Young Youl Hyun et al.

Cell transplantation, 21(11), 2425-2439 (2012-04-25)

T-cell dysregulation plays an important role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Adipose-derived stem cells (ASCs) have been reported to be able to prevent tissue damage through immune-modulating effects. To evaluate the effects of ASCs in high IgA

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Numero articolo commerciale globale

SKU	GTIN
A4937-.25ML	04061833375266
A4937-1ML	04061835805228
A4937-.5ML	04061837514333

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