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90469

(RS)-Mevalonic acid lithium salt

≥96.0% (GC)

Sinonimo/i:

(±)-MVA-Li, rac.-MVA-Li, Lithium (±)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (±)-3,5-dihydroxy-3-methyl-valerate

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Taglio della confezioneSKUDisponibilitàPrezzo
10 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 120.00
50 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 508.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C6H11O4 · xLi+
Numero CAS:
Peso molecolare:
147.15 (free acid basis)
MDL number:
UNSPSC Code:
12352107
NACRES:
NA.25
Assay:
≥96.0% (GC)
Form:
solid

CHF 120.00


Per conoscere la disponibilità, visualizza il carrello

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Quality Level

assay

≥96.0% (GC)

form

solid

composition

lithium, 2.2-4.7%

storage temp.

2-8°C

SMILES string

OC(CCO)(CC(=O)O)C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

InChI key

KJTLQQUUPVSXIM-UHFFFAOYSA-N

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Questo articolo
447144214743987
form

solid

form

-

form

-

form

-

assay

≥96.0% (GC)

assay

≥96.0% (GC)

assay

≥96.0% (GC)

assay

≥97.0% (GC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

composition

lithium, 2.2-4.7%

composition

-

composition

-

composition

-


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Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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The Journal of pharmacology and experimental therapeutics, 345(2), 180-188 (2013-02-22)
Tuberous sclerosis complex (TSC) is a multi-systemic syndrome caused by mutations in TSC1 or TSC2 gene. In TSC2-null cells, Rheb, a member of the Ras family of GTPases, is constitutively activated. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and block the
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The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
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Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in



Numero articolo commerciale globale

SKUGTIN
90469-50MG04061832393834
90469-10MG04061832393810
90469-250MG04061832393827

Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. can you confirm the RS isomer relative composition of the mixed isomer product 90469?

    1 answer
    1. The compound is labeled as (±) or racemic meaning there are an equal mix of R and S isomers. However, there are no optical activity assays performed on the final product to verify the exact compositions of the R and S isomers.

      Helpful?

  4. Is there any information available regarding the solubility of (RS)-Mevalonic acid lithium salt, Catalog 90469, for resuspension purposes?

    1 answer
    1. The solubility of (RS)-Mevalonic acid lithium salt is as follows:
      1. In H2O: 100 mg/mL (648.97 mM; ultrasonic agitation required)
      2.In DMSO: 50 mg/mL (324.49 mM; ultrasonic agitation required)

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  5. What is the recommended solution to dissolve this product in if wanting to add to cell culture media?

    1 answer
    1. This product is not tested for solubility. However various sources state that compound is soluble in water and PBS (may require sonication), as well as DMSO.

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