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53370

Sigma-Aldrich

L-istidina

≥99.0% (AT)

Sinonimo/i:

Acido L-α-amino-β-(4-imidazolil)propionico

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25 G
CHF 47.20
100 G
CHF 177.00
500 G
CHF 577.00

CHF 47.20

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25 G
CHF 47.20
100 G
CHF 177.00
500 G
CHF 577.00

About This Item

Formula empirica (notazione di Hill):
C6H9N3O2 · HCl · H2O
Numero CAS:
5934-29-2
Peso molecolare:
209.63
Beilstein:
4168261
Numero MDL:
MFCD00151027
Codice UNSPSC:
12352209
ID PubChem:
329757872
NACRES:
NA.77

CHF 47.20

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Livello qualitativo

100

Saggio

≥99.0% (AT)

Stato

solid

Attività ottica

[α]20/D +9.5±0.5°, c = 5% in 5 M HCl

Impurezze

≤0.3% foreign amino acids

Punto di fusione

254 °C (dec.) (lit.)

Solubilità

H2O: 1 g/10 mL, clear, colorless (hot)

Anioni in tracce

sulfate (SO42-): ≤100 mg/kg

Cationi in tracce

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
NH4+: ≤500 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Stringa SMILE

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1
CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Descrizione generale

L-Histidine is a hydrophilic essential amino acid that has a basic sidechain containing an imidazole group.

Azioni biochim/fisiol

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase[1][2]; it is also the precursor of histamine by action of histidine decarboxylase.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCCN0008
BCCN0007
BCCL7655
BCCJ2623
BCCH6305

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L-Histidine hydrochloride solution 100 mM amino acid in 0.1 M HCl, analytical standard

Supelco

43011

L-Histidine hydrochloride solution

L-Istidina suitable for cell culture, meets EP, USP testing specifications, from non-animal source

Sigma-Aldrich

H6034

L-Istidina

L-Histidine dihydrochloride ≥99.0% (AT)

Sigma-Aldrich

53340

L-Histidine dihydrochloride

Fosfato di sodio BioXtra, ≥98.0% (T)

Sigma-Aldrich

71645

Fosfato di sodio

L-arginina BioUltra, ≥99.5% (AT)

Sigma-Aldrich

11039

L-arginina

L-Histidine methyl ester dihydrochloride 97%

Sigma-Aldrich

H15403

L-Histidine methyl ester dihydrochloride

Sean E Lehman et al.
Journal of pharmaceutical sciences, 110(5), 1948-1957 (2021-01-17)
Protein aggregation can affect the quality of protein-based therapeutics. Attempting to unravel factors influencing protein aggregation involves systematic studies. These studies often include sodium azide or similar preservatives in the aggregation buffer. This work shows effects of azide on aggregation
Biochemistry, 3rd. ed. (New York, NY)
Stryer, L., W.H. Freeman
Biochemistry (3rd Edition), 19-20 (1988)
Textbook of Biochemistry with Clinical Correlations, 5th ed. (New York, NY)
Devlin, T. M., ed., Wiley-Liss
Biochemistry (5th Edition), 97-97 (2002)
Karla Viridiana Castro-Cerritos et al.
Bio-protocol, 7(23), e2634-e2634 (2017-12-05)
Elucidating how a population of non-growing bacteria generates mutations improves our understanding of phenomena like antibiotic resistance, bacterial pathogenesis, genetic diversity and evolution. To evaluate mutations that occur in nutritionally stressed non-growing bacteria, we have employed the strain B. subtilis
Martin Maldonado et al.
Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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