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Merck
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Documenti

51454

Sigma-Aldrich

Methicillin

≥95% (HPLC)

Sinonimo/i:

Sodium (2,6-dimethoxyphenyl)penicillin, Sodium methicillin

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About This Item

Formula empirica (notazione di Hill):
C17H19N2NaO6S
Numero CAS:
132-92-3
Peso molecolare:
402.40
Numero CE:
205-083-9
Numero MDL:
MFCD07787409
Codice UNSPSC:
51283503
ID PubChem:
329757690
NACRES:
NA.85

Origine biologica

synthetic

Saggio

≥95% (HPLC)

Forma fisica

powder

Colore

white to off-white

Spettro attività antibiotica

Gram-positive bacteria

Modalità d’azione

cell wall synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

[Na+].COc1cccc(OC)c1C(=O)N[C@H]2C3SC(C)(C)[C@@H](N3C2=O)C([O-])=O

InChI

1S/C17H20N2O6S.Na/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);/q;+1/p-1/t11-,12+,15-;/m1./s1
MGFZNWDWOKASQZ-UMLIZJHQSA-M

Categorie correlate

Applicazioni

Methicillin is used to study bacterium susceptibility , methicillin-resistance in Staphylococcus aureus , and to inhibit cell-wall synthesis .

Azioni biochim/fisiol

Methicillin inhibits cell wall synthesis. In Legionella pneumophila, methicillin causes the formation of membranous lesions through which cytoplasmic contents are lost .

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

Keep container tightly closed in a dry and well-ventilated place.Light sensitive

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H315,H317,H319,H334,H335

Classi di pericolo

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Paweł Kwiatkowski et al.
International journal of molecular sciences, 21(19) (2020-10-01)
This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of mecA gene and
Alex J McCarthy et al.
Veterinary dermatology, 23(4), 267-275 (2012-07-25)
Meticillin-resistant Staphylococcus aureus (MRSA) continues to pose a major threat to human health. In animals, MRSA has become established as a veterinary pathogen in pets and horses; in livestock, it presents a concern for public health as a reservoir that
F G Rodgers et al.
Journal of medical microbiology, 31(1), 37-44 (1990-01-01)
The response of Legionella pneumophila to antibiotics that inhibit cell-wall, protein and DNA synthesis was examined by electronmicroscopy, MIC estimations and viable counts. Ampicillin, cefotaxime, methicillin, erythromycin, rifampicin and ciprofloxacin, each used separately at 20 times their respective MIC values
Ulla Ruffing et al.
PloS one, 7(12), e52487-e52487 (2013-01-04)
As genotyping of S. aureus is important for epidemiologic research and for hygiene management, methods are required for standardized fast and easily applicable evaluation of closely related epidemic strains with high prevalence in hospitals. In this single centre matched control
Wei Zhu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(1), 123-128 (2012-12-19)
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. We report here the discovery and X-ray crystallographic structures of 10 chemically diverse compounds (benzoic, diketo, and phosphonic acids, as well as a
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