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485A-1

ATRX Rabbit Polyclonal Antibody

Name: ATRX Rabbit Polyclonal Antibody
Brand: SIGMA

Sinonimo/i:

ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP)

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Informazioni su questo articolo

UNSPSC Code:

41116161

Conjugate:

unconjugated

Species reactivity:

human

Application:

ICC

Citations:

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Servizio Tecnico

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Proprietà

biological source

rabbit blood

Quality Level

100, 500

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (485A-14)), vial of 0.1 mL (concentrate (485A-14-RUO) Research Use Only), vial of 0.5 mL (concentrate (485A-15)), vial of 1.0 mL (concentrate (485A-16)), vial of 1.0 mL (concentrate (485A-16-RUO) Research Use Only), vial of 1.0 mL (concentrate (485A-17-RUO) Research Use Only), vial of 1.0 mL (pre-dilute ready-to-use (485A-17)), vial of 7.0 mL (concentrate (485A-18-RUO) Research Use Only), vial of 7.0 mL (pre-dilute ready-to-use (485A-18))

manufacturer/tradename

Cell Marque^®

technique(s)

immunocytochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:50-1:50 (concentrated))

isotype

IgG

control

astrocytoma, brain, glioblastoma, oligodendroglioma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Descrizione

General description

Diffuse gliomas are classified based on histological and molecular features to achieve an integrated diagnosis. Molecular diagnostic markers include IDH mutation, 1p/19q co-deletion, and TP53 mutation. ATRX is a chromatin remodeling protein and its mutation status may be used as a molecular diagnostic marker within the diff use glioma classification algorithm. Anti-ATRX is used to identify mutant ATRX by a loss of ATRX expression in neoplastic cells when compared with internal positive controls (endothelial cells, glia, and neurons). Grade II/III astrocytoma classification includes IDH mutant, ATRX mutant, and 1p/19q retention, while grade II/III oligodendroglioma includes IDH mutant, ATRX wildtype, and 1p/19q co-deletion; p53 expression may also serve as an aid in diagnosis. ATRX mutation is frequently, but not always, mutually exclusive with 1p/19q co-deletion.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: [email protected]

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Classe di stoccaggio

12 - Non Combustible Liquids

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Utility of ATRX immunohistochemistry in diagnosis of adult diffuse gliomas.

Masako Ikemura et al.

Histopathology, 69(2), 260-267 (2016-01-08)

We performed an immunohistochemical analysis of alpha-thalassaemia/mental retardation syndrome X-linked (ATRX) expression in adult diffuse gliomas, with reference to clinicopathological and genetic features, to determine the utility of this analysis in diagnostic practice. A total of 193 adult diffuse gliomas

Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.

Matthew D Wood et al.

Diagnostic pathology, 14(1), 29-29 (2019-04-11)

Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on

Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion.

Akane Yamamichi et al.

Brain tumor pathology, 35(2), 106-113 (2018-03-20)

The IDH-mutant and 1p/19q co-deletion (1p19q codel) provides significant diagnostic and prognostic value in lower-grade gliomas. As ATRX mutation and 1p19q codel are mutually exclusive, ATRX immunohistochemistry (IHC) may substitute for 1p19q codel, but this has not been comprehensively examined.