44270
trans,trans-Farnesyl pyrophosphate ammonium salt
≥95.0% (HPLC)
Sinonimo/i:
(E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt, Farnesyl diphosphate ammonium salt
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 10 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 959.00 CHF 719.25 | |
| 50 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 3’830.00 CHF 2’872.50 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C15H28O7P2 · xNH3
Peso molecolare:
382.33 (free acid basis)
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352212
Beilstein/REAXYS Number:
2482197
Assay:
≥95.0% (HPLC)
Form:
solid
CHF 719.25
Prezzo di listinoCHF 959.00Risparmia il 25%Promozione valida solo online
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
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Permettici di aiutartiQuality Level
assay
≥95.0% (HPLC)
form
solid
storage temp.
−20°C
SMILES string
N.C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
1S/C15H28O7P2.H3N/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18;/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18);1H3/b14-9+,15-11+;
InChI key
CPYJTMLHKIWGDF-NDHHSALASA-N
Application
Farnesyl diphosphate ammonium salt may be used to study the posttranslational process known as farnesylation that is used to modify important proteins such as the Ras oncogene.
Biochem/physiol Actions
Farnesyl pyrophosphate is a key intermediate in the biosynthesis of more complex sesquiterpenoids, higher terpenoids, and steroids[1] and different biological functions have been discovered for FPP and the corresponding alcohol farnesol[2][3][4][5][6][7]. FPP plays an important role in the posttranslational processing of Ras proteins. Mutated forms of Ras are associated with human cancer and are therefore investigated in cancer research[5][6].
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
Questo articolo | |||
|---|---|---|---|
| form solid | form methanol:ammonia solution | form - | form powder |
| assay ≥95.0% (HPLC) | assay ≥95% (TLC) | assay ≥95.0% (HPLC) | assay ≥95.0% (TLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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S M Sebti et al.
Oncogene, 19(56), 6584-6593 (2001-06-28)
In 1990, more than 10 years after the discovery that the low molecular weight GTPase Ras is a major contributor to human cancer, farnesylation, a lipid posttranslational modification required for the cancer-causing activity of Ras, emerged as a major target
Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase.
Subramanian T, Pais JE, Liu S, et al.
Biochemistry (2012)
Po-Huang Liang et al.
European journal of biochemistry, 269(14), 3339-3354 (2002-07-24)
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| 44270-50MG | 04061832404363 |
| 44270-10MG | 04061832282718 |