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29447

Sigma-Aldrich

(24S)-24,25-Dihydroxyvitamin D3

≥95.0% (HPLC)

Sinonimo/i:

(24S)-24,25-Dihydroxycholecalciferol

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About This Item

Formula empirica (notazione di Hill):
C27H44O3
Numero CAS:
55700-58-8
Peso molecolare:
416.64
Numero MDL:
MFCD11114064
Codice UNSPSC:
12352200
ID PubChem:
329753335

Livello qualitativo

100

Saggio

≥95.0% (HPLC)

Stato

powder or crystals

Colore

colorless to white

Punto di fusione

114.6 °C

Temperatura di conservazione

−20°C

Stringa SMILE

C[C@H](CC[C@H](O)C(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25+,27-/m1/s1
FCKJYANJHNLEEP-WQUHCOROSA-N

Azioni biochim/fisiol

Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24S,25-Dihydroxyvitamin D3 should not be confused with 24R,25-Dihydroxyvitamin D3.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300

Consigli di prudenza

P264 - P301 + P310

Classi di pericolo

Acute Tox. 2 Oral

Codice della classe di stoccaggio

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCBV8192
BCBV3033
BCBV2328
BCBS9409V
BCBP2180V

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H L Henry et al.
The Journal of nutrition, 106(6), 724-734 (1976-06-01)
The ability of 24R, 25- and 24S, 25-dihydroxycholecalciferol to stimulate intestinal calcium transport and bone calcium mobilization in chicks was measured. Enhancement of intestinal calcium transport by 325 or 130 nmoles of either compound was maximal by 24 hours. The
José Pérez Sestelo et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(12), 2747-2752 (2002-10-24)
Vitamin D3 active metabolites 24R,25-(OH)2-D3, 24S,25-(OH)2-D3, and 1 alpha, 24R,25-(OH)3-D3 were synthesized by a convergent and stereoselective approach. In the synthetic route, the stereogenic center at C-24 was generated through ultrasonically induced aqueous conjugate addition of iodide 6 to Seebach's
S Ishizuka et al.
Archives of biochemistry and biophysics, 234(1), 97-104 (1984-10-01)
Tritium-labeled 24,25-dihydroxyvitamin D3 was prepared both in vitro, by using chick kidney homogenates, and in vivo in rats from [26,27-methyl-3H]25-hydroxyvitamin D3. These compounds were mixed with synthetic 24(R),25- and 24(S),25-dihydroxyvitamin D3, converted to the corresponding trimethylsilyl ether derivatives, and analyzed
Anjali Verma et al.
Steroids, 150, 108447-108447 (2019-07-16)
Vitamin D has long been prescribed as a supplement to breast cancer patients. This is partially motivated by data indicating that low serum vitamin D, measured as 25-hydroxyvitamin D3 [25(OH)D3], is associated with worsened cancer prognosis and decreased survival rates
Anjali Verma et al.
Molecular cancer research : MCR, 19(1), 99-111 (2020-10-22)
Vitamin D3 and its metabolites have antitumorigenic properties in vitro and in vivo; however, clinical trials and retrospective studies on the effectiveness of vitamin D3 oral supplementation against cancer have been inconclusive. One reason for this may be that clinical

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