10385

Angiotensin III trifluoroacetate salt hydrate

≥98% (HPCE)

• Sinonimo/i: Des-Asp-1-Angiotensin II trifluoroacetate salt hydrate
• Formula empirica (notazione di Hill): C₄₆H₆₆N₁₂O₉ · xC₂HF₃O₂ · yH₂O
• Numero CAS: 12687-51-3
• Peso molecolare: 931.09 (anhydrous free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 57646800
• MDL number: MFCD20264812
• Beilstein/REAXYS Number: 8385695
• Assay: ≥98% (HPCE)
• Quality level: 100

Proprietà

• Quality Level: 100
• assay: ≥98% (HPCE)
• solubility: H₂O: 1.0 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: O.OC(=O)C(F)(F)F.CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C46H66N12O9.C2HF3O2.H2O/c1-5-27(4)38(57-40(61)33(21-29-15-17-31(59)18-16-29)53-42(63)37(26(2)3)56-39(60)32(47)13-9-19-51-46(48)49)43(64)54-34(23-30-24-50-25-52-30)44(65)58-20-10-14-36(58)41(62)55-35(45(66)67)22-28-11-7-6-8-12-28;3-2(4,5)1(6)7;/h6-8,11-12,15-18,24-27,32-38,59H,5,9-10,13-14,19-23,47H2,1-4H3,(H,50,52)(H,53,63)(H,54,64)(H,55,62)(H,56,60)(H,57,61)(H,66,67)(H4,48,49,51);(H,6,7);1H2/t27-,32-,33-,34-,35-,36-,37-,38-;;/m0../s1
• InChI key: JEOAJMGVSAMVML-UFPGTABSSA-N

Descrizione

General description

Angiotensin III (Ang III) is a 7-AA bioactive peptide that is formed from the degradation of the Angiotensin II peptide by aminopeptidase A; both are derivatives of angiotensinogen and are components of the renin-angiotensin system (RAS).

Arg-Val-Tyr-Ile-His-Pro-Phe-OH.3CH₃COOH.4H₂O

Biochem/physiol Actions

Angiotensin III is an AT₁ and AT₂ agonist, with higher sensitivity for the AT₂ receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release[1] and a stimulator for aldosterone release.[2]

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)