76307

4-(2-aminoetil)benzene solfonil fluoruro

• Sinonimo/i: AEBSF
• Formula empirica (notazione di Hill): C₈H₁₀FNO₂S · HCl
• Numero CAS: 30827-99-7
• Peso molecolare: 239.69
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329767025
• MDL number: MFCD00132962
• Beilstein/REAXYS Number: 7604627

Proprietà

• assay: ≥95.0% (HPLC)
• Quality Segment: 200
• form: powder or crystals
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• storage temp.: 2-8°C
• SMILES string: FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
• InChI: 1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
• InChI key: WRDABNWSWOHGMS-UHFFFAOYSA-N

Descrizione

General description

Pefabloc^® SC is a potent, nontoxic and relatively easy to use, irreversible serine proteinase inhibitor. It is reported to efficiently inhibit the platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase) in both humans and rats.

Pefabloc^® SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

Application

Si raccomanda l′impiego di concentrazioni tra 0,1 e 1 mM.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pefabloc^® SC may be used as an analytical standard in determining the native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes. It may also be used as an esterase inhibitor, which is added to the whole blood to improve the stability of ciclesonide for the determination of ciclesonide (CIC) and its active metabolite, desisobutyryl-ciclesonide (des-CIC), in human plasma using liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric (LC-APCI-MS/MS) method.

Biochem/physiol Actions

Il cloridrato di 4-(2-amminoetil)benzensolfonilfluoruro (AEBSF) è un inibitore irreversibile delle serin-proteasi. Le costanti di inibizione sono simili a quelle del fenilmetansolfonilfluoruro (PMSF) e del diisopropilfluorofosfato (DFP). È stato dimostrato che l'AEBSF è in grado di inibire la tripsina, la chimotripsina, la plasmina, la callicreina e la trombina. Quale alternativa a PMSF e DFP, l'AEBSF offe minore tossicità, migliore solubilità in acqua e migliore stabilità nelle soluzioni acquose. L'AEBSF può essere utilizzato nelle colture cellulari in concentrazioni fino a 0,25 mM.

Other Notes

Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic[1]; Unaffected by albumin[2]

Legal Information

Pefabloc is a registered trademark of Pentapharm

Informazioni sulla sicurezza

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1A
• Classe di stoccaggio: 8A - Combustible corrosive hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges