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MABC95

Anti-S1PR2/EDG5 Antibody, clone 6E8.1

clone 6E8.1, from mouse

Sinonimo/i:

Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5

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Taglio della confezioneSKUDisponibilitàPrezzo
100 μg
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CHF 453.00

Informazioni su questo articolo

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
6E8.1, monoclonal
Application:
IHC, WB
Citations:
2

CHF 453.00


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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6E8.1, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

isotype

IgMκ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... S1PR2(9294)

General description

Sphingosine 1-phosphate receptor 2 (S1PR2), otherwise known as EDG5, is a ubiquitous G-protein coupled receptor for lysosphingolipid sphingosine 1-phosphate (S1P). It is coupled to Gi, G12/13, and Gq pathways to regulate a number of second messengers and effector molecules, including cAMP, PLC, MAPK, RhoA, and Rac. S1PR2 mediates the effects of S1P on cell motility and embryonic development, among other cellular processes.
~35 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human S1PR2/EDG5.

Application

Anti-S1PR2/EDG5 Antibody, clone 6E8.1 detects level of S1PR2/EDG5 & has been published & validated for use in Western Blotting, IHC(P).
Immunohistochemistry Analysis: A representative lot detected S1PR2/EDG5 in human tonsil, liver, colorectal cancer tissues.

Biochem/physiol Actions

This antibody recognizes the cytoplasmic domain of S1PR2/EDG5.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected S1PR2/EDG5 in 10 mg of human liver tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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SAB4503615MABC94MABC97
biological source

mouse

biological source

rabbit

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... S1PR2(9294)

Gene Information

human ... S1PR2(9294)

Gene Information

human ... S1PR1(1901)

Gene Information

human ... S1PR4(8698)

clone

6E8.1, monoclonal

clone

polyclonal

clone

8B7.1, monoclonal

clone

16B9.1, monoclonal

species reactivity

human

species reactivity

rat, human, mouse

species reactivity

mouse, human, rat

species reactivity

rat, human


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wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Classe di stoccaggio

12 - Non Combustible Liquids



Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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T H Beckham et al.
Oncogenesis, 2, e49-e49 (2013-06-05)
Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide, sphingosine and sphingosine 1-phosphate (S1P). These bioactive sphingolipids have diverse, powerful and often oppositional impacts on
Xiao-Jing Sun et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(8), 1313-1322 (2017-02-17)
C5a plays a crucial role in anti-neutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. Our previous studies found that the interaction between sphingosine-1-phosphate (S1P) and C5a plays an important role in the ANCA-mediated activation of neutrophils. In the current study



Numero articolo commerciale globale

SKUGTIN
MABC9504053252697753

Questions

  1. Laut Human Protein Atlas gibt es einen S1PR2 Antikörper von Sigma mit der Nummer HPA014307. Ich kann Ihn leider nicht mehr finden. Ist der Antikörper noch verfügbar?

    1 answer
    1. Unfortunately, HPA014307 is currently not available. This product is an anti-S1PR2/EDG5 antibody.

      Please see the link below to review another anti-S1PR2/EDG5 antibody that may be of interest: https://www.sigmaaldrich.com/US/en/product/sigma/sab2501413

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