07-574
Anti-CENP-A Antibody
Upstate®, from rabbit
Sinonimo/i:
Anti-CENP-A, Anti-CenH3
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200 μL
CHF 501.00
CHF 501.00
Spedizione prevista il21 maggio 2025
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Cambia visualizzazione
200 μL
CHF 501.00
About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
CHF 501.00
Spedizione prevista il21 maggio 2025
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human
Produttore/marchio commerciale
Upstate®
tecniche
western blot: suitable
Isotipo
IgG
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CENPA(1058)
Descrizione generale
CENP-A is a variant version of histone H3 found only at centromeres.
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
Specificità
Broad species cross-reactivity is predicted.
CENP-A
Immunogeno
peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A
Applicazioni
Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Qualità
routinely evaluated by immunoblot in acid extracted histones from HeLa cells
Descrizione del bersaglio
17kDa
Linkage
Replaces: 04-205
Stato fisico
Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
ImmunoAffinity Purified
Stoccaggio e stabilità
Stable for 1 year at 2 to 8ºC from date of receipt.
Risultati analitici
Control
Control Histones (from Hela cells) colcemid-treated or untreated
Control Histones (from Hela cells) colcemid-treated or untreated
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Qubo Zhu et al.
The Journal of cell biology, 185(5), 827-839 (2009-06-03)
Telomeric repeat binding factor 1 (TRF1) is a component of the multiprotein complex "shelterin," which organizes the telomere into a high-order structure. TRF1 knockout embryos suffer from severe growth defects without apparent telomere dysfunction, suggesting an obligatory role for TRF1
CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells.
Athwal, RK; Walkiewicz, MP; Baek, S; Fu, S; Bui, M; Camps, J; Ried, T; Sung, MH; Dalal, Y
Epigenetics & Chromatin null
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.
Roshan L Shrestha et al.
Journal of cell science, 136(10) (2023-05-02)
Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and human cells. Even though overexpression and mislocalization of
Yujue Chen et al.
The Journal of cell biology, 220(7) (2021-04-22)
Centromeric transcription has been shown to play an important role in centromere functions. However, lack of approaches to specifically manipulate centromeric transcription calls into question that the proposed functions are a direct consequence of centromeric transcription. By monitoring nascent RNAs
Qinfu Chen et al.
Cell reports, 36(12), 109740-109740 (2021-09-23)
Bub1 is required for the kinetochore/centromere localization of two essential mitotic kinases Plk1 and Aurora B. Surprisingly, stable depletion of Bub1 by ∼95% in human cells marginally affects whole chromosome segregation fidelity. We show that CENP-U, which is recruited to
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