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28221

Oxacillin Natriumsalz

815-950 μg/mg (Oxacillin)

Synonym(e):

Sodium 5-methyl-3-phenyl-4-isoxazolyl penicillin

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Über diesen Artikel

Empirische Formel (Hill-System):
C19H18N3NaO5S
CAS-Nummer:
Molekulargewicht:
423.42
UNSPSC Code:
51283505
NACRES:
NA.85
PubChem Substance ID:
EC Number:
214-636-3
Beilstein/REAXYS Number:
4098179
MDL number:
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biological source

synthetic

Quality Level

form

powder

concentration

815-950 μg/mg (Oxacillin)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].Cc1onc(-c2ccccc2)c1C(=O)N[C@H]3C4SC(C)(C)[C@@H](N4C3=O)C([O-])=O

InChI

1S/C19H19N3O5S.Na/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);/q;+1/p-1/t13-,14+,17?;/m1./s1

InChI key

VDUVBBMAXXHEQP-ZTRPPZFVSA-M

General description

Chemical structure: β-lactam

Application

Oxacillin is used to study mechanisms of penicillinase resistance and antimicrobial susceptibility [1]. It has been used to study autolysins[2]

Biochem/physiol Actions

Oxacillin inhibits bacterial cell wall biosynthesis at the level of transpeptidation (PBP) of peptidoglycan. Used to study mechanisms of penicillinase resistance.

Packaging

1g, 5g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Dieser Artikel
27555C9393A8351
antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder or crystals

form

powder or crystals

form

powder

concentration

815-950 μg/mg (Oxacillin)

concentration

-

concentration

-

concentration

-

biological source

synthetic

biological source

semisynthetic

biological source

-

biological source

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C


Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1



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Daniel G Lloyd et al.
Antimicrobial agents and chemotherapy, 65(1) (2020-10-14)
Bacterial pathogens are rapidly evolving resistance to all clinically available antibiotics. One part of the solution to this complex issue is to better understand the resistance mechanisms to new and existing antibiotics. Here, we focus on two antibiotics. Teixobactin is
G K Best et al.
Antimicrobial agents and chemotherapy, 6(6), 825-830 (1974-12-01)
A comparison of the autolytic enzyme activity in Staphylococcus aureus strains that differ markedly in their rates of lysis and killing after exposure to oxacillin has been made. Log-phase cells of the clinical isolate that is tolerant to oxacillin inhibition
Sinisa Bratulic et al.
Nature communications, 8, 15410-15410 (2017-05-20)
Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli



Global Trade Item Number

SKUGTIN
28221-1G04061826227695
28221-5G04061826227749

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