27555

Cloxacillin Natriumsalz

≥95.0% (HPLC)

• Synonym(e): 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt, Syntarpen sodium salt
• Empirische Formel (Hill-System): C₁₉H₁₇ClN₃NaO₅S
• CAS-Nummer: 642-78-4
• Molekulargewicht: 457.86
• Beilstein: 4103180
• EG-Nummer: 211-390-9
• MDL-Nummer: MFCD00063568
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 57648259
• NACRES: NA.85

Eigenschaften

• Biologische Quelle: semisynthetic
• Assay: ≥95.0% (HPLC)
• Form: powder or crystals
• Verunreinigungen: ≤5% Total impurities (anhydrous)
• Farbe: white to off-white
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: cell wall synthesis | interferes
• Lagertemp.: 2-8°C
• SMILES String: [Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
• InChI: 1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
• InChIKey: SCLZRKVZRBKZCR-SLINCCQESA-M

Beschreibung

Allgemeine Beschreibung

Chemical structure: ß-lactam

Anwendung

Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness[1] and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria[2].

Biochem./physiol. Wirkung

Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)