S3322

Supercinnamaldehyde

≥98% (HPLC)

• Synonym(e): 1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one
• Empirische Formel (Hill-System): C₁₂H₁₁NO₂
• CAS-Nummer: 70351-51-8
• Molekulargewicht: 201.22
• NACRES: NA.77
• PubChem Substance ID: 329824530
• UNSPSC Code: 12352200
• MDL number: MFCD08530327
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 200

Eigenschaften

• Quality Level: 200
• assay: ≥98% (HPLC)
• form: powder
• color: faintly red to very dark red
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)C(=C\C(C)=O)\c2ccccc12
• InChI: 1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7+
• InChI key: CZKBLHCEDVWPRN-JXMROGBWSA-N

Beschreibung

Application

Supercinnamaldehyde may be used in transient receptor potential ankyrin 1 (TRPA 1)-mediated cell signaling studies.

Biochem/physiol Actions

Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator. EC₅₀ = 0.8 μM.

Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC₅₀ = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.

Disclaimer

Air-sensitive

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves