S3322

Supercinnamaldehyde

≥98% (HPLC)

• Synonym(e): 1,3-Dihydro-1-methyl-3-(2-oxopropylidene)-2H-Indol-2-one
• Empirische Formel (Hill-System): C₁₂H₁₁NO₂
• CAS-Nummer: 70351-51-8
• Molekulargewicht: 201.22
• MDL-Nummer: MFCD08530327
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824530
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: faintly red to very dark red
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: CN1C(=O)C(=C\C(C)=O)\c2ccccc12
• InChI: 1S/C12H11NO2/c1-8(14)7-10-9-5-3-4-6-11(9)13(2)12(10)15/h3-7H,1-2H3/b10-7+
• InChIKey: CZKBLHCEDVWPRN-JXMROGBWSA-N

Beschreibung

Anwendung

Supercinnamaldehyde may be used in transient receptor potential ankyrin 1 (TRPA 1)-mediated cell signaling studies.

Biochem./physiol. Wirkung

Supercinnamaldehyde is a transient receptor potential ankyrin 1 (TRPA1) activator; EC₅₀ = 0.8 μM; derivative of cinnamaldehyde; covalently binds to and activates TRPA1 receptor (expressed in nociceptive neurons) by modifying its cysteine residues. Covalent modification of reactive cysteines within TRPA1 can cause channel activation, rapidly signaling potential tissue damage through the pain pathway.

Vorsicht

Air-sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves