Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

N129

Sigma-Aldrich

Naloxone methiodide

≥98% (HPLC), solid

Synonym(e):

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

Empirische Formel (Hill-System):
C20H24INO4
CAS-Nummer:
93302-47-7
Molekulargewicht:
469.31
MDL-Nummer:
MFCD00078592
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24897480
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Arzneimittelkontrolle

regulated under CDSA - not available from Sigma-Aldrich Canada

Farbe

white to tan

Löslichkeit

H2O: >10 mg/mL

Lagertemp.

2-8°C

SMILES String

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChIKey

ICONPJDAXITIPI-UXYWFNEESA-N

Verwandte Kategorien

Anwendung

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem./physiol. Wirkung

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 3

1 of 3

Yttrium chips, 99.9% trace rare earth metals basis

Sigma-Aldrich

262994

Yttrium

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt ≥97% (HPLC)

Sigma-Aldrich

E7384

[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt

Naltrexon -hydrochlorid

Sigma-Aldrich

N3136

Naltrexon -hydrochlorid

Piotr Wojciechowski et al.
European journal of pharmacology, 885, 173514-173514 (2020-08-30)
PK20M (Dmt-D-Lys-Phe-Phe-OH) is a novel modified endomorphin-2 (EM-2) peptide producing strong dose- and time-dependent antinociceptive activity. Yet its prototype, endogenous EM-2, has been reported to trigger respiratory and vascular effects such as apnea and hypotension. The purpose of this study
Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.
Mélanie Kremer et al.
Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)
Helvira Melo et al.
Scientific reports, 8(1), 15551-15551 (2018-10-21)
Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated
Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates
Lewanowitsch Tanya and Irvine RJ
Brain Research, 964(2), 302 -3305 (2003)
Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal
Lewanowitsch Tanya and Irvine RJ
European Journal of Pharmacology, 445(1-2), 61 -667 (2002)
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.