B7273

Bezafibrat

≥98%, peroxisome proliferator-activated receptor agonist, solid

• Synonym(e): 2-{4-[2-(4-Chlorbenzoylamino)-ethyl]-phenoxy}-2-methylpropionsäure
• Empirische Formel (Hill-System): C₁₉H₂₀ClNO₄
• CAS-Nummer: 41859-67-0
• Molekulargewicht: 361.82
• NACRES: NA.77
• PubChem Substance ID: 24891983
• UNSPSC Code: 12352200
• EC Number: 255-567-9
• MDL number: MFCD00078970
• Assay: ≥98%
• Form: solid

Eigenschaften

• Produktname: Bezafibrat, ≥98%, solid
• Quality Segment: 200
• assay: ≥98%
• form: solid
• solubility: DMF: soluble, deionized water: insoluble, methanol: soluble
• originator: Roche
• SMILES string: CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O
• InChI: 1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)
• InChI key: IIBYAHWJQTYFKB-UHFFFAOYSA-N
• Gene Information: human ... HBA2(3040), PPARA(5465), PPARD(5467), PPARG(5468) ; mouse ... Ppara(19013), Ppard(19015), Pparg(19016)

Beschreibung

Application

Bezafibrate has been used:

• a supplement in the standard diet (SD) for mice to study its effect on diabetes
• to evaluate its effect on hepatitis C virus (HCV) assembly and secretion[1]
• to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

Biochem/physiol Actions

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.[1]

Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.

The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves