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B7273

Sigma-Aldrich

Bezafibrat

≥98%, solid

Synonym(e):

2-{4-[2-(4-Chlorbenzoylamino)-ethyl]-phenoxy}-2-methylpropionsäure

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About This Item

Empirische Formel (Hill-System):
C19H20ClNO4
CAS-Nummer:
41859-67-0
Molekulargewicht:
361.82
EG-Nummer:
255-567-9
MDL-Nummer:
MFCD00078970
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24891983
NACRES:
NA.77

Assay

≥98%

Form

solid

Löslichkeit

DMF: soluble
deionized water: insoluble
methanol: soluble

Ersteller

Roche

SMILES String

CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(O)=O

InChI

1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24)

InChIKey

IIBYAHWJQTYFKB-UHFFFAOYSA-N

Angaben zum Gen

human ... HBA2(3040) , PPARA(5465) , PPARD(5467) , PPARG(5468)
mouse ... Ppara(19013) , Ppard(19015) , Pparg(19016)

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Verwandte Kategorien

Anwendung

Bezafibrate has been used:
  • a supplement in the standard diet (SD) for mice to study its effect on diabetes
  • to evaluate its effect on hepatitis C virus (HCV) assembly and secretion
  • to evaluate its effect on gonadal steroidogenesis and spermatogenesis of zebrafish and also used as standard for HPLC

Biochem./physiol. Wirkung

Bezafibrate has the ability to repress HCV assembly and secretion. It is used to treat dyslipidemia.
The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid nuclear receptor superfamily. Bezafibrate is a peroxisome proliferator-activated receptor agonist for PPARα, PPARδ, and PPARγ. Lipoprotein lipase (LPL) activator.
PPARgamma agonists, including Bezafibrate, have beneficial effects in the suppression of the inflammatory response during RSV infection and therefore might have clinical efficacy in the course of severe RSV-infection.

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Sigma-Aldrich

C7081

WY-14643

Fenofibrat United States Pharmacopeia (USP) Reference Standard

USP

1269447

Fenofibrat

Fenofibrinsäure analytical standard

Supelco

90568

Fenofibrinsäure

GW7647 ≥98% (HPLC)

Sigma-Aldrich

G6793

GW7647

Atenolol ≥98% (TLC), powder

Sigma-Aldrich

A7655

Atenolol

Dipyridamol ≥98% (HPLC)

Sigma-Aldrich

D9766

Dipyridamol

Pravastatin sodium salt hydrate ≥98% (HPLC), powder

Sigma-Aldrich

P4498

Pravastatin sodium salt hydrate

GW501516 ≥98% (HPLC)

Sigma-Aldrich

SML1491

GW501516

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice
Franko A, et al.
Molecular Metabolism, 6(3), 256-266 (2017)
Marc Engelen et al.
PloS one, 7(7), e41013-e41013 (2012-08-23)
X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ABCD1 gene and is characterized by impaired beta-oxidation of very-long-chain fatty acids (VLCFA) and subsequent VLCFA accumulation in tissues. In adulthood X-ALD most commonly manifests as a gradually progressive myelopathy, (adrenomyeloneuropathy;
Zhihong Ye et al.
Water research, 184, 115986-115986 (2020-07-20)
This work reports the novel application of an Fe-based 2D metal-organic framework (MOF), prepared with 2,2'-bipyridine-5,5'-dicarboxylate (bpydc) as organic linker, as highly active catalyst for heterogeneous photoelectro-Fenton (PEF) treatment of the lipid regulator bezafibrate in a model matrix and urban
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-induced diabetic mice
Franko A, et al.
Diabetes, 65(9), 2540-2552 (2016)
Magali Dumont et al.
Human molecular genetics, 21(23), 5091-5105 (2012-08-28)
Peroxisome proliferator-activated receptors (PPARs) are ligand-mediated transcription factors, which control both lipid and energy metabolism and inflammation pathways. PPARγ agonists are effective in the treatment of metabolic diseases and, more recently, neurodegenerative diseases, in which they show promising neuroprotective effects.
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Artikel

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