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Merck

PPARA

peroxisome proliferator-activated receptor alpha

Synonyms:
NR1C1, PPAR, PPARalpha, hPPAR
Species:
Human PPARA (5465), Mouse Ppara (19013), Rat Ppara (25747), domestic guinea pig Ppara (100135604), chicken PPARA (374120), naked mole-rat Ppara (101725514), Domestic Rabbit PPARA (100009308), Goat PPARA (100861393), sheep PPARA (100190976), dog PPARA (403654) ...More
UniProtKB ID:
Q07869, B0G0X3, Q16241, Q6I9S0, Q92486, Q92689, Q9Y3N1
Gene ID:
  • Human(5465) Summary: Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
  • Mouse(19013) peroxisome proliferator activated receptor alpha
  • Rat(25747) peroxisome proliferator activated receptor alpha
  • domestic guinea pig(100135604) peroxisome proliferator activated receptor alpha
  • chicken(374120) peroxisome proliferator-activated receptor alpha
  • naked mole-rat(101725514) peroxisome proliferator-activated receptor alpha
  • Domestic Rabbit(100009308) peroxisome proliferator-activated receptor alpha
  • Goat(100861393) peroxisome proliferator-activated receptor alpha
  • sheep(100190976) peroxisome proliferator-activated receptor alpha
  • dog(403654) peroxisome proliferator-activated receptor alpha
  • Horse(100049840) peroxisome proliferator-activated receptor alpha
  • domestic cat(101095837) peroxisome proliferator-activated receptor alpha
  • domestic cat(100049013) peroxisome proliferator-activated receptor alpha
  • cow(281992) peroxisome proliferator-activated receptor alpha

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Small Molecule - Activator

Product Number
Description
Species
F6020
Fenofibrate, ≥99%, powder,
Species
human
197777
2-(p-Chlorophenoxy)-2-methylpropionic acid, 97%,
Species
mouse, human
C7081
WY-14643, ,
Species
rat, human, mouse
B7273
Bezafibrate, ≥98%, solid,
Species
mouse, human

Small Molecule - Agonist

Product Number
Description
Species
F0048010
Fenofibrate impurity B, European Pharmacopoeia (EP) Reference Standard,
Species
human
G9518
Gemfibrozil, ,
Species
human
C0330
Ciprofibrate, ,
Species
human
C2300000
Clofibrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
41326
Clofibrate, analytical standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
T2573
Troglitazone, ≥98% (HPLC),
Species
human
G3295
GW0742, ≥98% (HPLC),
Species
human
O0383
N-Oleoylethanolamine, ~98% (TLC),
Species
human, mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
SAB2101852
Anti-PPARA antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rat
Application
western blot
SAB4502260
Anti-PPAR-α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
AV34113
Anti-PPARA antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
SAB1406277
Anti-PPARA antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
ZRB2372
Anti-PPARα Antibody, clone 4G22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
SRP2043
PPAR, α human, recombinant, expressed in E. coli, ≥75% (SDS-PAGE),
Species
human
SRP2134
PPARα isotype, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human
SRP2054
PPARα, ligand binding domain (170-468) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human
SRP2135
PPARα isotype, ligand binding domain, GST tagged human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
EHU151821
MISSION® esiRNA, targeting human PPARA,
Species
human