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95144

Sigma-Aldrich

Retinol

BioXtra, ≥97.5% (HPLC), ~3100 U/mg

Synonym(e):

Axerophthol, Vitamin A, Vitamin A1, Vitamin-A-alkohol, all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol

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250 MG
CHF 194.00
1 G
CHF 597.00

CHF 194.00

Voraussichtliches Versanddatum31. Mai 2025

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250 MG
CHF 194.00
1 G
CHF 597.00

About This Item

Empirische Formel (Hill-System):
C20H30O
CAS-Nummer:
68-26-8
Molekulargewicht:
286.45
Beilstein:
403040
EG-Nummer:
200-683-7
MDL-Nummer:
MFCD00001552
UNSPSC-Code:
12352205
eCl@ss:
34058018
PubChem Substanz-ID:
57653654
NACRES:
NA.28

CHF 194.00

Voraussichtliches Versanddatum31. Mai 2025

Bulk-Bestellung anfordern

Biologische Quelle

synthetic

Produktlinie

BioXtra

Assay

≥97.5% (HPLC)

Form

(Powder or Powder with Lumps)

Spezifische Aktivität

~3100 U/mg

Haltbarkeit

limited shelf life

Farbe

faint yellow to very dark yellow

mp (Schmelzpunkt)

56-61 °C
61-63 °C (lit.)

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

InChIKey

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

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Verwandte Kategorien

Allgemeine Beschreibung

Retinol or vitamin A alcohol is the main circulating form of vitamin A.[1]

Anwendung

Retinol has been used:
  • as a standard in peak identification and quantification in reverse phase HPLC[2]
  • as a standard to estimate the concentration of vitamin A[3]
  • to study the inhibitory effect of retinol on murine norovirus (MNV) replication in murine RAW 264.7 cells[4]
  • as a component in the reaction mixture for the lecithin:retinol acyltransferase (LRAT) assay[5]

Biochem./physiol. Wirkung

It is not biologically active and works as a precursor of active retinoids. Retinol is converted to retinaldehyde and subsequently to retinoic acid.[1]
Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Einheitendefinition

1 U entspricht 1 Internationalen Einheit gemäss Ph Eur II, 217 (1983)

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCL8551
BCCM6917
0000393018
0000393018
BCCM5486

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Vitamin A water-miscible 1 ml = 200,000 I.U. for oral use, EMPROVE® ESSENTIAL, Ph. Eur., BP

SAFC

5.00849

Vitamin A

Retinylpalmitat Type IV, ~1,800,000 USP units/g, oil

Sigma-Aldrich

R3375

Retinylpalmitat

Retinyl-propionat ≥98.0% (sum of isomers, HPLC), ~2500 U/mg

Sigma-Aldrich

87809

Retinyl-propionat

vibrant-m

R0290000

Retinolester

9-cis-Retinal vitamin A analog

Sigma-Aldrich

R5754

9-cis-Retinal

Retinylacetat analytical standard

Supelco

46958

Retinylacetat

Retinylacetat – wasserlöslich BioReagent, suitable for cell culture

Sigma-Aldrich

R0635

Retinylacetat – wasserlöslich

Heetae Lee et al.
Scientific reports, 6, 25835-25835 (2016-05-18)
The effect and underlying mechanism of vitamin A on norovirus infection are largely unknown. This study aimed to investigate how vitamin A administration affects the gut microbiome after norovirus infection. Here, we demonstrate that treatment with either retinol or retinoic
Understanding the physiological role of retinol-binding protein in vitamin A metabolism using transgenic and knockout mouse models
Quadro L, et al.
Molecular Aspects of Medicine, 24(6), 421-430 (2003)
Retinyl palmitate does not have an adjuvant effect on the antibody response of chicks to keyhole limpet hemocyanin regardless of vitamin A status
Livingston KA and Klasing KC
Poultry Science, 90(5), 965-970 (2011)
Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome
Lee H and Ko G
Scientific reports, 25835-25835 (2016)
Responses of blood metabolites and proteins to different vitamin A levels in Korean native steers.
Wang T, et al.
Pakistan journal of botany, 34(4) (2014)
Alle zugehörigen Dokumente anzeigen

Protokolle

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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