1370462

Losartan-Kalium

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 2-Butyl-4-chlor-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Imidazol-5-methanol-Kaliumsalz, 2-Butyl-4-chlor-1-{[2′-(1H-tetrazol-5-yl)-(1,1′-biphenyl)-4-yl]-methyl}-1H-imidazol-5-methanol Monokaliumsalz, DuP 753, Kalium-5-(4′-((2-butyl-4-chlor-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-id, MK 954
• Empirische Formel (Hill-System): C₂₂H₂₂ClKN₆O
• CAS-Nummer: 124750-99-8
• Molekulargewicht: 461.00
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750264
• MDL number: MFCD02092704
• Beilstein/REAXYS Number: 5845770

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: losartan
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• InChI key: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• Gene Information: human ... AGTR1(185)

Beschreibung

General description

Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.[1]

Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.[1]

Application

Losartan potassium USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Losartan Potassium and Hydrochlorothiazide Tablets
• Losartan Potassium Tablets

Biochem/physiol Actions

Losartankalium ist ein oral verabreichter, wirksamer und selektiver kompetitiver Angiotensin-II-Rezeptortyp-1(AT1)-Antagonist. Losartankalium wird zur Behandlung von Hypertonie eingesetzt.

Oral verabreichter, wirksamer und selektiver kompetitiver Angiotensin-II-Rezeptortyp-1(AT1)-Antagonist

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable