T7329

Taurolidin

>97% (NMR), powder

• Synonym(e): 4,4′-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide), Taurolin, Tauroline
• Empirische Formel (Hill-System): C₇H₁₆N₄O₄S₂
• CAS-Nummer: 19388-87-5
• Molekulargewicht: 284.36
• NACRES: NA.77
• PubChem Substance ID: 329826864
• UNSPSC Code: 12352200
• EC Number: 243-016-5
• MDL number: MFCD00865076
• Assay: >97% (NMR)
• Form: powder
• Storage condition: protect from light

Eigenschaften

• Quality Segment: 100
• assay: >97% (NMR)
• form: powder
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2
• InChI: 1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
• InChI key: AJKIRUJIDFJUKJ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Taurolidine is a broad spectrum antibiotic with antineoplastic activity, which induces apoptosis and decreases tumor cell proliferation. Taurolidine has been used with TNF-related-apoptosis-inducing ligand (TRAIL) to characterize synergistic responses in many apoptosis related signaling-proteins. Tauroline is also being used as a tool to study the various mechanisms of apoptosis and necrosis.

Taurolidine is a broad spectrum antibiotic with antineoplastic activity; induces apoptosis and decreases tumor cell proliferation.

Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors[1]. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections[2].

Preparation Note

Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable