P2745

Protein Phosphatase Inhibitor 1 human

• Synonym(e): Inhibitor 1 human
• UNSPSC Code: 12352202
• NACRES: NA.77
• MDL number: MFCD01635659

Eigenschaften

• biological source: human
• Quality Segment: 200
• recombinant: expressed in E. coli
• assay: >95% (SDS-PAGE)
• form: solution
• mol wt: ~31 kDa, apparent mol wt ~27 kDa
• UniProt accession no.: Q12972, Q13522
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... PPP1R1A(5502), PPP1R8(5511)

Beschreibung

Application

This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.[1]

Biochem/physiol Actions

Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.

Physical form

Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable