N2001

Neostigminbromid

≥98% (HPLC and titration), acetylcholinesterase inhibitor, powder

• Synonym(e): 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine
• Empirische Formel (Hill-System): C₁₂H₁₉BrN₂O₂
• CAS-Nummer: 114-80-7
• Molekulargewicht: 303.20
• NACRES: NA.77
• PubChem Substance ID: 24277854
• UNSPSC Code: 12352200
• EC Number: 204-054-8
• MDL number: MFCD00011795
• Assay: ≥98% (HPLC and titration)
• Form: powder

Eigenschaften

• Produktname: Neostigminbromid, ≥98% (HPLC and titration), powder
• assay: ≥98% (HPLC and titration)
• form: powder
• color: white
• mp: 175-177 °C (lit.)
• solubility: H₂O: 1 g/mL, ethanol: soluble
• SMILES string: [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
• InChI: 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• InChI key: LULNWZDBKTWDGK-UHFFFAOYSA-M
• Gene Information: human ... ACHE(43)

Beschreibung

Application

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

• to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
• to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
• to study its effects on depolarization of bag cell neurons.[1]

Biochem/physiol Actions

Reversibler Inhibitor der Acetylcholinesterase, der die Blut-Hirn-Schranke nicht überquert.

Reversibler Inhibitor der Acetylcholinesterase; ähnlich zu Eserin, überquert aber nicht die Blut-Hirn-Schranke.

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H310 + H330,H315,H317,H319,H334,H335
• pcodes: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges