M7068

MPP dihydrochloride hydrate

≥97% (HPLC), powder, estrogen receptor α agonist

• Synonym(e): 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride hydrate, Methyl-piperidino-pyrazole hydrate
• Empirische Formel (Hill-System): C₂₉H₃₁N₃O₃ · 2 HCl · xH₂O
• CAS-Nummer: 911295-24-4
• Molekulargewicht: 542.50 (anhydrous basis)
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724540
• NACRES: NA.77
• MDL number: MFCD06411603
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: DMSO: soluble ≥20 mg/mL
• SMILES string: Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
• InChI: 1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
• InChI key: FWDNPWVVRVSJQH-UHFFFAOYSA-N

Beschreibung

General description

Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.[1]

Application

MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:

• in human breast cancer MCF-7 cells[2]
• to pre-treat endometrial ex vivo organ cultures (EVOCs)[3]
• to treat pituitary glands to monitor luteinizing hormone secretion[4]

Biochem/physiol Actions

MPP dihydrochloride is a specific estrogen receptor α antagonist.

Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β.[1] It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.[2]

Specific estrogen receptor α antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves