E7906

Esomeprazole Magnesiumsalz Hydrat

≥98% (HPLC)

• Synonym(e): (T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium Hydrat, Nexium, Omeprazole
• Empirische Formel (Hill-System): C₃₄H₃₆MgN₆O₆S₂ · xH₂O
• CAS-Nummer: 668985-31-7
• Molekulargewicht: 713.12 (anhydrous basis)
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799074
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -128 to -146°, c = 0.5 in methanol
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥5 mg/mL
• Ersteller: AstraZeneca
• Lagertemp.: 2-8°C
• SMILES String: O.COc1ccc2n([Mg]n3c(nc4cc(OC)ccc34)S(=O)Cc5ncc(C)c(OC)c5C)c(nc2c1)S(=O)Cc6ncc(C)c(OC)c6C
• InChI: 1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;/t2*24-;;/m00../s1
• InChIKey: LGRFYKXKCZKDLS-DIYDTZFBSA-N

Beschreibung

Allgemeine Beschreibung

Esomeprazole is the (S)-isomer of omeprazole. It blocks the H⁺/K⁺-ATPase enzyme and lowers the release of hydrochloric acid by gastric parietal cells. Esomeprazole is used for treating gastroesophageal reflux disease (GERD).

Anwendung

Esomeprazole magnesium hydrate has been used to induce intracellular acidification in an ATP12A-independent manner.

Biochem./physiol. Wirkung

Esomeprazole magnesium dihydrate is a leading proton pump inhibitor.

Leistungsmerkmale und Vorteile

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)