Fortfahren mit
C4615
Cloricromene
≥98% (HPLC), solid
Synonym(e):
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride, AD6
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Über diesen Artikel
Empirische Formel (Hill-System):
C20H26ClNO5 · HCl
CAS-Nummer:
Molekulargewicht:
432.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
white
mp
221-222.3 °C
solubility
DMSO: 17 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
Cl[H].CCOC(=O)COc1ccc2C(C)=C(CCN(CC)CC)C(=O)Oc2c1Cl
InChI
1S/C20H26ClNO5.ClH/c1-5-22(6-2)11-10-15-13(4)14-8-9-16(26-12-17(23)25-7-3)18(21)19(14)27-20(15)24;/h8-9H,5-7,10-12H2,1-4H3;1H
InChI key
CCCZJRFQJNGCCU-UHFFFAOYSA-N
Biochem/physiol Actions
Antithrombotic coumarin derivative that inhibits platelet and leukocyte function and suppresses arachidonic acid liberation by interfering with PLA2 activation.
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Claudio Bucolo et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 23(3), 257-263 (2007-06-27)
The aim of this study was to evaluate the retina and plasma distribution of cloricromene, a coumarin derivative, and its active metabolite (MET) after an oral administration in rabbits and rats. A single dose of cloricromene was orally administered to
Claudio Bucolo et al.
Investigative ophthalmology & visual science, 50(8), 3846-3852 (2009-03-13)
Retinal microvascular cells play a crucial role in the pathogenesis of diabetic retinopathy. The endothelial effects of cloricromene, a novel coumarin derivative, on diabetic retinopathy induced by streptozotocin (STZ) in the rat were investigated. Cloricromene (10 mg/kg intraperitoneally) was administered
R Pignatello et al.
The Journal of pharmacy and pharmacology, 58(7), 1001-1005 (2006-06-30)
The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but
L Groban et al.
Clinical and experimental pharmacology & physiology, 25(6), 417-423 (1998-07-23)
1. The aim of the present investigation was to evaluate the effect of cloricromene on myocardial infarct size, regional myocardial blood flow and neutrophil accumulation in a canine model of ischaemia-reperfusion. 2. Dogs were instrumented to measure blood pressure, left
D A Zvara et al.
Anesthesia and analgesia, 84(2), 266-270 (1997-02-01)
Cloricromene is a coumarin derivative without anticoagulant activities that has recently been found to decrease myocardial infarct size after an ischemic-reperfusion injury. This study seeks to determine when the cardioprotective action of cloricromene is exerted in an in vivo rabbit
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C4615-5MG | 04061833269886 |
| C4615-25MG | 04061833269879 |
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