C0621

CI−994

≥98% (HPLC), HDAC Inhibitor, powder

• Synonym(e): 4-Acetylamino-N-(2′-aminophenyl)benzamide, Acetyldinaline, Tacedinaline
• Empirische Formel (Hill-System): C₁₅H₁₅N₃O₂
• CAS-Nummer: 112522-64-2
• Molekulargewicht: 269.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774808
• NACRES: NA.77
• MDL number: MFCD00866266
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: CI−994, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
• InChI: 1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
• InChI key: VAZAPHZUAVEOMC-UHFFFAOYSA-N
• Gene Information: human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

Beschreibung

Application

CI-994 has been used:

• as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effects
• as an HDAC inhibitor for screening in SPEL cells
• to study its effects on human myeloid and erythroid progenitors

Biochem/physiol Actions

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.

Orally available HDAC Inhibitor; CI-994 blocks cells in the G1-S phase of the cell cycle.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves