![Benzo[a]pyrene ≥96% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/253/820/be96d879-1811-46c0-8f11-612019691c2d/640/be96d879-1811-46c0-8f11-612019691c2d.png)
This product can be stored at room temperature.
Fortfahren mit
B1760
Benzo[a]pyren
≥96% (HPLC)
Synonym(e):
3,4-Benzopyren, 3,4-Benzpyren, Benz[def]chrysen
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 100 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 138.00 | |
| 500 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 330.00 | |
| 1 g | Warenkorb auf Verfügbarkeit prüfen | CHF 599.00 | |
| 5 g | Warenkorb auf Verfügbarkeit prüfen | CHF 2’400.00 CHF 2’040.00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H12
CAS-Nummer:
Molekulargewicht:
252.31
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-028-5
Beilstein/REAXYS Number:
1911333
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Level
assay
≥96% (HPLC)
form
solid
bp
495 °C (lit.)
mp
177-180 °C (lit.)
SMILES string
c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
InChI
1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H
InChI key
FMMWHPNWAFZXNH-UHFFFAOYSA-N
Application
Benzo[a]pyren (PAH), ein polyzyklischer aromatischer Kohlenwasserstoff und Umweltschadstoff wird als chemisches Karzinogen in experimentellen Krebsmodellen verwendet. Die Karzinogenese ist abhängig von der durch CYP1A1 veranlassten Oxidation zu Benzo[a]pyren-diol-epoxid, das mit der DNA depurinierende Addukte bildet, welche sich trennen und abasische Läsionen bilden. Benzo[a]pyren ist ein Ligand für den Aryl-Hydrocarbon-Rezeptor (AhR) und einige seiner biologischen Wirkungen, wie die Induktion von 1A1, scheinen durch die Aktivierung des AhR vermittelt zu werden.
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Dieser Artikel | |||
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| assay ≥96% (HPLC) | assay - | assay - | assay - |
| form solid | form - | form - | form - |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level 100 |
| bp 495 °C (lit.) | bp 495 °C (lit.) | bp 495 °C (lit.) | bp 495 °C (lit.) |
| mp 177-180 °C (lit.) | mp 177-180 °C (lit.) | mp 177-180 °C (lit.) | mp 177-180 °C (lit.) |
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signalword
Danger
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - PBT - Repr. 1B - Skin Sens. 1 - vPvB
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
Ariel Revel et al.
Journal of applied toxicology : JAT, 23(4), 255-261 (2003-07-29)
Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts. Because BaP metabolization requires cytochrome
Yi-Chen Lin et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-17)
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because the pollutant may negatively affect many physiological systems. As such, chronic exposure to
Audrey Barranger et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-11)
This study aimed to assess the ecotoxicological effects of the interaction of fullerene (C60) and benzo[a]pyrene (B[a]P) on the marine mussel, Mytilus galloprovincialis. The uptake of nC60, B[a]P and mixtures of nC60 and B[a]P into tissues was confirmed by Gas
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B1760-100MG | 04061833426364 |
| B1760-250MG | 04061833426371 |
| B1760-1G | 04061835542826 |
| B1760-5G | 04061835512171 |
| B1760-500MG | 04061833426388 |
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At what temperature should this reagent be stored?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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