A8727

Antalarmin hydrochloride

≥98% (HPLC), solid, CRF1 antagonist

• Synonym(e): N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride
• Empirische Formel (Hill-System): C₂₄H₃₄N₄·HCl
• CAS-Nummer: 220953-69-5
• Molekulargewicht: 415.01
• MDL-Nummer: MFCD05664721
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724401
• NACRES: NA.77

Eigenschaften

• product name: Antalarmin hydrochloride, ≥98% (HPLC), solid
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: off-white
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
• InChI: 1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
• InChIKey: CGDGXEDXEXACKQ-UHFFFAOYSA-N

Beschreibung

Anwendung

Antalarmin hydrochloride has been used:

• to study its effect on stress-induced tryptophan hydroxylase 2 activity
• to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
• to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biochem./physiol. Wirkung

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)