A0788

3-Aminobenzamid

≥99% (TLC)

• Synonym(e): 3-AB, 3-ABA
• Lineare Formel: H₂NC₆H₄CONH₂
• CAS-Nummer: 3544-24-9
• Molekulargewicht: 136.15
• EG-Nummer: 222-586-9
• MDL-Nummer: MFCD00007989
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278206
• NACRES: NA.77

Eigenschaften

• Assay: ≥99% (TLC)
• Form: powder
• Farbe: white to off-white
• mp (Schmelzpunkt): 115-116 °C (lit.)
• Löslichkeit: ethanol: 50 mg/mL, clear, light yellow; DMSO: soluble; H₂O: soluble (may require gentle heating)
• Lagertemp.: room temp
• SMILES String: NC(=O)c1cccc(N)c1
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• InChIKey: GSCPDZHWVNUUFI-UHFFFAOYSA-N
• Angaben zum Gen: mouse ... Parp1(11545)

Beschreibung

Anwendung

3-Aminobenzamide has been used as a poly-(ADP-ribose) polymerase (PARP) inhibitor in various experimental studies.[1][2][3]

Biochem./physiol. Wirkung

3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents.[4] It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS).[5] 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury[5] and local inflammation.[6]

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves