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53886
Tn-Antigen
≥99.0% (TLC), powder or crystals
Synonym(e):
GalNac-α-1-O-serin, O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serin
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 1 mg | Warenkorb auf Verfügbarkeit prüfen | CHF 368.00 CHF 312.80 |
Über diesen Artikel
Empirische Formel (Hill-System):
C11H20N2O8
CAS-Nummer:
Molekulargewicht:
308.29
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
CHF 312.80
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Unterstützung erhaltenProduktname
Tn-Antigen, ≥99.0% (TLC)
Quality Level
assay
≥99.0% (TLC)
form
powder or crystals
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key
REDMNGDGDYFZRE-WKWISIMFSA-N
General description
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥99.0% (TLC) | assay ≥95.0% (TLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 300 |
| form powder or crystals | form powder or crystals | form - | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. 2-8°C |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation
Liu Z, et al.
Journal of Cellular and Molecular Medicine (2019)
Brian R Stotter et al.
American journal of physiology. Renal physiology, 318(2), F518-F530 (2020-01-07)
Mucin-type O-linked glycosylation, a posttranslational modification affecting the stability and biophysical characteristics of proteins, requires C1GalT1 (T synthase) and its obligate, X-linked chaperone Cosmc. Hypomorphic C1GalT1 mutations cause renal failure via not yet established mechanisms. We hypothesize that impaired Cosmc-dependent
Neha M Sahasrabudhe et al.
Biological chemistry, 399(7), 649-659 (2018-06-13)
Colorectal cancer is the third most common cancer type worldwide. It is characterized by a high expression of aberrantly glycosylated ligands, such as the Tn antigen (GalNAcα1-Ser/Thr), which is a major ligand for the C-type lectin macrophage galactose-type lectin (MGL).
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 53886-1MG | 04061825700052 |