T1001
Thyroglobulin aus Rinderschilddrüse
powder, ≥90% (agarose gel electrophoresis)
Synonym(e):
Globulins thyro, Thyractin
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About This Item
Empfohlene Produkte
Biologische Quelle
bovine thyroid
Assay
≥90% (agarose gel electrophoresis)
Form
powder
Mol-Gew.
~670 kDa
Zusammensetzung
Iodine, ≥0.20%
Stickstoffbestimmung
13.0-16.0% total
Asche
≤4%
Löslichkeit
H2O: 20 mg/mL
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
cow ... TG(280706)
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Anwendung
Wird oft als Träger-Protein für die Produktion von Antikörpern eingesetzt. Sein Vorteil ist die große Zahl von Tyrosinresten, die für die Konjugation in Diazo-Reaktionen verwendet werden können.
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Biochem./physiol. Wirkung
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
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N Murat Karabacak et al.
Molecular & cellular proteomics : MCP, 8(4), 846-856 (2008-12-17)
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Nature ecology & evolution, 1(5), 109-109 (2017-08-16)
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