P6249

p53 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

• NACRES: NA.25
• UNSPSC Code: 12352202
• Form: buffered aqueous glycerol solution
• Assay: ≥90% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli

Eigenschaften

• biological source: human
• Quality Segment: 200
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• UniProt accession no.: P04637
• application(s): genomic analysis
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TP53(7157)

Beschreibung

General description

GST-tagged, full-length human p53

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain. [1]

Application

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Biochem/physiol Actions

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable