P5057

Paromomycin -sulfat (Salz)

powder, suitable for cell culture, BioReagent

• Empirische Formel (Hill-System): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS-Nummer: 1263-89-4
• Molekulargewicht: 615.63 (free base basis)
• Beilstein: 5715182
• UNSPSC-Code: 12352207
• PubChem Substanz-ID: 24898585
• NACRES: NA.76

Eigenschaften

• product name: Paromomycin -sulfat (Salz), powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg
• Produktlinie: BioReagent
• Qualitätsniveau: 200
• Form: powder
• Wirksamkeit: ≥675 μg per mg
• Methode(n): cell culture | mammalian: suitable
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• SMILES String: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• InChIKey: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: aminoglycoside

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Anwendung

• Paromomycin sulfate salt has been used as a:
• reference compound in antileishmanial activity
• RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.

Recommended for use in cell culture applications at 100mg/L.

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Biochem./physiol. Wirkung

Paromomycin hemmt die Initiation und Elongation der Proteinsynthese durch Bindung an 16S ribosomale RNA. Paromomycin bindet an der A-Stelle, wodurch defekte Polypeptidketten entstehen und zum Zelltod führen.

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Sonstige Hinweise

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable